推荐产品
化驗
≥95% (HPLC)
形狀
lyophilized
成份
Peptide Content, ≥55%
儲存條件
protect from light
儲存溫度
−20°C
Amino Acid Sequence
Arg-Lys-Leu-Leu-Trp-NH2
一般說明
组织蛋白酶L抑制剂是一种组蛋白H3加工酶。它在维持表皮稳态、毛囊正常形态发生和周期中起重要作用。组织蛋白酶L参与蛋白降解。它可能会调节免疫系统的正常功能。组织蛋白酶L可调节巨噬细胞死亡、坏死核心形成和动脉粥样硬化斑块不稳定进展。
應用
组织蛋白酶L是一种可代谢胶原蛋白和弹性蛋白的溶酶体半胱氨酸蛋白酶。组织蛋白酶L的作用和活性可借助肽抑制剂如五肽酰胺RKLLW-NH2（Arg-Lys-Leu-Leu-Trp-NH2）而得以研究。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Protease signalling: the cutting edge
Turk B, et al.
The Embo Journal, 31(7), 1630-1643 (2012)
Cathepsin L expression and regulation in human abdominal aortic aneurysm, atherosclerosis, and vascular cells
Liu J, et al.
Atherosclerosis, 184(2), 302-311 (2006)
Cathepsin L is significantly associated with apoptosis and plaque destabilization in human atherosclerosis
Li W, et al.
Atherosclerosis, 202(1), 92-102 (2009)
V Turk et al.
The EMBO journal, 20(17), 4629-4633 (2001-09-05)
From their discovery in the first half of the 20th century, lysosomal cysteine proteases have come a long way: from being the enzymes non-selectively degrading proteins in lysosomes to being those responsible for a number of important cellular processes. Some
A Brinker et al.
European journal of biochemistry, 267(16), 5085-5092 (2000-08-10)
By screening a combinatorial pentapeptide amide collection in an inhibition assay, we systematically evaluated the potential of 19 proteinogenic amino acids and seven nonproteinogenic amino acids to serve as building blocks for inhibitors of human cathepsin L. Particularly efficient were
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门