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Merck

C7268

Sigma-Aldrich

胰凝乳蛋白酶抑制剂

powder

别名:

N-(Nα-羰基-Cpd-X-Phe-al)-Phe(Cpd = 环氧环氧环己烷)(环氧环氧环己烷= [S,S]-α-(2-亚氨基六氢-4-嘧啶基)甘氨酸)

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About This Item

CAS号:
MDL號碼:
分類程式碼代碼:
12352202
PubChem物質ID:
NACRES:
NA.77

product name

胰凝乳蛋白酶抑制剂, microbial

生物源

microbial

品質等級

形狀

powder

溶解度

DMSO: 10 mM (Stock solutions stable for months at −20 °C.)

儲存溫度

−20°C

SMILES 字串

OC(C(NC(NC(C1NC(NCC1)=N)C([F,Cl,Br,I]C)=O)=O)CC2=CC=CC=C2)=O

InChI 密鑰

MRXDGVXSWIXTQL-HYHFHBMOSA-N

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應用

胰凝乳蛋白酶抑制剂已用于一项研究,该研究确定分子计算可用于评估配对模型中配体(包括抑制剂和同源酶)之间的相互作用。胰凝乳蛋白酶抑制剂也被用于研究诺罗病毒蛋白酶作为抗病毒药物开发的有吸引力的靶标。

生化/生理作用

抑制溶酶体组织蛋白酶 B 和可溶性激活蛋白酶。许多幼嫩的植物组织都表达一种胰凝乳蛋白酶抑制剂敏感性丝氨酸蛋白酶。
糜蛋白酶抑制蛋白是许多蛋白酶的强抑制剂,包括糜蛋白酶、木瓜蛋白酶、糜蛋白酶样丝氨酸蛋白酶、糜蛋白酶和溶酶体半胱氨酸蛋白酶如组织蛋白酶 A、B、C、B、H 和 L。它对人白细胞弹性蛋白酶的抑制作用较弱。在终浓度为 100~200 μg/ml (10~100 μM) 时有效。胰凝乳蛋白酶抑制剂通常包含在与植物提取物一起使用的蛋白酶抑制剂混合物中。

其他說明

A(主要)、B 和 C 组分的混合物。A:X = 亮氨酸;B:X = 缬氨酸;C:X = 异亮氨酸
胰凝乳蛋白酶抑制剂 A 分子量 = 607.7
胰凝乳蛋白酶抑制剂 B 分子量 = 593.7
胰凝乳蛋白酶抑制剂 C 分子量 = 607.7

準備報告

在 10 mg/mL 冰醋酸中进行溶解度试验,得到澄清溶液,其通常为无色,但外观可能为黄色。据研究报道,它也可溶于 DMSO;微溶于水和短链醇;不溶于乙酸乙酯、乙酸丁酯、乙醚、己烷和石油醚。可在 DMSO 中制备贮备液 (10 mM),并在-20°C 条件下可稳定数月。也可在 0.1 MHCl 中制备贮备液。由于末端醛发生氧化,稀释溶液 (10-100 μM) 仅可稳定数小时。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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Analytical Enzyme Chymotrypsin: Chymotrypsin is produced in the acinar cells of the pancreas as the inactive precursor, chymotrypsinogen.

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