SML0525

kb-NB142-70

≥97% (HPLC)

• 别名: 3,4-Dihydro-9-hydroxy-[1]benzothieno[2,3-f]-1,4-thiazepin-5(2H)-one
• 经验公式（希尔记法）: C₁₁H₉NO₂S₂
• CAS号: 1233533-04-4
• 分子量: 251.32
• MDL號碼: MFCD18086915
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329825531
• NACRES: NA.77

属性

• 化驗: ≥97% (HPLC)
• 形狀: powder
• 顏色: white to beige
• 溶解度: DMSO: 10 mg/mL, clear
• 儲存溫度: 2-8°C
• SMILES 字串: Oc1ccc2sc3C(=O)NCCSc3c2c1
• InChI: 1S/C11H9NO2S2/c13-6-1-2-8-7(5-6)9-10(16-8)11(14)12-3-4-15-9/h1-2,5,13H,3-4H2,(H,12,14)
• InChI 密鑰: DHUAGGSHTKPOHU-UHFFFAOYSA-N

说明

生化／生理作用

kb-NB142-70 is a derivative of the PKD1 inhibitor CID755673, with approximately 6-fold greater potency (IC₅₀ for inhibition of PKD1 = 28.3 nM vs. 182 nM for CID755673). kb-NB142-70 dose dependently inhibits proliferation of PC3 prostate cancer cell, and blocks migration of the prostate cancer lines PC3 and DU145.

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable