推荐产品
产品名称
罗氟司特, ≥98% (HPLC)
化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: 20 mg/mL, clear
儲存溫度
−20°C
SMILES 字串
ClC1=CN=CC(Cl)=C1NC(C2=CC=C(OC(F)F)C(OCC3CC3)=C2)=O
InChI
1S/C17H14Cl2F2N2O3/c18-11-6-22-7-12(19)15(11)23-16(24)10-3-4-13(26-17(20)21)14(5-10)25-8-9-1-2-9/h3-7,9,17H,1-2,8H2,(H,22,23,24)
InChI 密鑰
MNDBXUUTURYVHR-UHFFFAOYSA-N
基因資訊
human ... PDE4A(5141) , PDE4B(5142) , PDE4C(5143) , PDE4D(5144)
應用
罗氟司特已被用于评估其对小鼠熏烟法模型中急性肺部炎症和慢性肺部改变的影响。此外，它还可用于研究其在长期增效 (LTP)缓解原胚细胞诱发的缺陷方面的治疗潜力。
生化／生理作用
罗氟司特是一种高效、口服有效的选择性磷酸二酯酶4 (PDE4) 抑制剂。
罗氟司特是一种高效、口服有效的选择性磷酸二酯酶4 (PDE4) 抑制剂，IC50 为 0.8 nM。罗氟司特具有抗炎作用，用于临床治疗COPD。
特點和優勢
这种化合物是环核苷酸研究的特色产品。点击此处发现更多特色环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
訊號詞
Warning
危險聲明
危險分類
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
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