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生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 52 kDa
物種活性
human, rat, mouse
濃度
~1 mg/mL
技術
ELISA: 1:1000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... PPARA(5465)
一般說明
Anti-PPAR-α antibody detects endogenous levels of total PPAR-α protein.
The PPAR-α (peroxisome proliferator-activated receptor α) gene is mapped to human chromosome 22q13.31. Ppar-α is localized to the nucleus.
免疫原
The antiserum was produced against synthesized peptide derived from human PPAR-alpha.
Immunogen Range: 6-55
Immunogen Range: 6-55
生化／生理作用
PPAR-α (peroxisome proliferator-activated receptor α) is a receptor transcription factor that inhibits inflammation, by preventing the nuclear factor κB activation. Omega-3 long-chain polyunsaturated fatty acids is known to be the ligand that brings out the anti-inflammatory action of Ppar-α. Ppar-α is involved in epidermal proliferation and differentiation and therefore serves as a skin barrier. PPARα mediates lipid metabolism by inducing fatty acid oxidation and also regulates glucose metabolism. Variation in the gene is observed in schizophrenia.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Microdeletions involving chromosomes 12 and 22 associated with syndromic Duane retraction syndrome.
Abu-Amero KK
Ophthalmic Genetics, 35(3), 162-169 (2014)
An association between the PPAR?-L162V polymorphism and nicotine dependency among patients with schizophrenia.
Nadalin S
Comprehensive Psychiatry, 70, 118-124 (2016)
Nutrient-sensing nuclear receptors PPAR? and FXR control liver energy balance.
Preidis GA
The Journal of Clinical Investigation, 127(4), 1193-1201 (2017)
Role of PPAR? in the attenuation of bile acid-induced apoptosis by omega-3 long-chain polyunsaturated fatty acids in cultured hepatocytes.
Tillman EM
Pediatric Research, 79(5), 754-758 (2016)
Eupatilin with PPAR? agonistic effects inhibits TNF?-induced MMP signaling in HaCaT cells.
Jung Y
Biochemical and Biophysical Research Communications, 493(1), 220-226 (2017)
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
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