推荐产品
生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
IgG fraction of antiserum
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
35 kDa
物種活性
human
濃度
0.5-1 mg/mL
技術
immunoblotting: suitable
immunohistochemistry: suitable
登錄號
NM_000427
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... LOR(4014)
一般說明
The LOR gene codes for a a small basic protein, loricrin. It is predominantly localized to the cornified cell envelope.
免疫原
Synthetic peptide directed towards the N terminal region of human LOR
生化／生理作用
LOR is a major protein component of the cornified cell envelope found in terminally differentiated epidermal cells. Mutations in this gene are associated with Vohwinkel′s syndrome and progressive symmetric erythrokeratoderma, both inherited skin diseases.LOR encodes loricrin, a major protein component of the cornified cell envelope found in terminally differentiated epidermal cells. Mutations in LOR may be the cause of both Vohwinkel′s syndrome and progressive symmetric erythrokeratoderma, both inherited skin diseases.
Mutations in the gene LOR, leads to an autosomal dominant genodermatosis called loricrin keratoderma. The disease is characterized by palmoplantar keratoderma and ichthyosis. Variation in the gene also results in Vohwinkel syndrome with ichthyosis and progressive symmetrical erythrokeratodermia, an inherited cornification disorder.
序列
Synthetic peptide located within the following region: GYSGGGCGGGSSGGGGGGGIGGCGGGSGGSVKYSGGGGSSGGGSGCFSSG
外觀
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Novel autosomal dominant mutation in loricrin presenting as prominent ichthyosis.
Pohler E, et al.
British Journal of Dermatology, 173(5), 1291-1294 (2015)
Evidence for the absence of mutations at GJB3, GJB4 and LOR in progressive symmetrical erythrokeratodermia.
Wei S, et al.
Clinical and Experimental Dermatology, 36(4), 399-405 (2011)
Activation of vascular endothelial growth factor receptor 2 in a cellular model of loricrin keratoderma.
Yoneda K, et al.
The Journal of Biological Chemistry (2010)
Kinga Skieresz-Szewczyk et al.
Cells, 11(12) (2022-06-25)
The lingual mucosa in birds is covered with two specific types of multilayered epithelia, i.e., the para- and orthokeratinized epithelium, that differ structurally and functionally. Comprehensive information on proteins synthesized in keratinocyte during their cytodifferentiation in subsequent layers of multilayered
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