Q3625

奎尼丁

sodium channel blocker

• 经验公式（希尔记法）: C₂₀H₂₄N₂O₂
• CAS号: 56-54-2
• 分子量: 324.42
• Beilstein: 91866
• EC號碼: 200-279-0
• MDL號碼: MFCD00135581
• 分類程式碼代碼: 12352200
• PubChem物質ID: 24899331
• NACRES: NA.77

属性

• product name: 奎尼丁, anhydrous
• 等級: anhydrous
• 品質等級: 200
• 雜質: ≤20% Dihydroquinidine (according to USP specifications., actual content given on label)
• mp: 168-172 °C (lit.)
• 起源: Bayer
• SMILES 字串: COc1ccc2nccc([C@H](O)C3CC4CCN3C[C@@H]4C=C)c2c1
• InChI: 1S/C20H24N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3/t13-,14-,19+,20-/m0/s1
• InChI 密鑰: LOUPRKONTZGTKE-LHHVKLHASA-N
• 基因資訊: human ... ABCB1(5243) , CYP2D6(1565) , CYP3A4(1576) , KCNH1(3756) , SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335) ; mouse ... Abcb1a(18671) , Abcb1b(18669) ; rat ... Cyp2d1(266684) , Cyp2d2(25053) , Cyp2d3(24303) , Cyp2d4v1(171522)

说明

應用

Quinidine has been used:

• as an inhibitor of cytochrome P450 enzyme isoform CYP2D6
• as a potassium (K⁺) channel blocker in microglia
• to test its effect on electrophysiological behaviour of human induced pluripotent stem cells (hiPSC) cardiomyocytes

生化／生理作用

Quinidine, an isomer of quinine has potential side effects like proarrhythmia on usage. It prolongs cardiac potential and is sodium channel blocker. It is a potential antagonist for α1-adrenoceptors and contributes to hypotension. It inhibits cytochrome P450 2D6 and improves circulation and brain penetration of dementia drug, dextromethorphan. Quinidine-dextromethorphan combination may be useful in treating pseudobulbar affect (PBA).

IA 类抗心律失常药；钾通道阻断剂。

特點和優勢

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全信息

• 象形圖: GHS06
• 訊號詞: Danger
• 危險聲明: H301,H317
• 防範說明: P261 - P264 - P272 - P280 - P301 + P310 - P302 + P352
• 危險分類: Acute Tox. 3 Oral - Skin Sens. 1
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 1
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Faceshields, Gloves