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形狀
powder
顏色
white
儲存溫度
room temp
InChI
1S/C21H27N2O2.HI/c1-4-14-13-23(2)10-8-15(14)11-20(23)21(24)17-7-9-22-19-6-5-16(25-3)12-18(17)19;/h4-7,9,12,14-15,20-21,24H,1,8,10-11,13H2,2-3H3;1H/q+1;/p-1/t14-,15?,20+,21-,23?;/m0./s1
InChI 密鑰
AJQSDVGBERUTGX-QVEQJUGRSA-M
應用
NMQ/N-methyl-quinidine - MDR1/P-gp substrate has been used as a probe substrate for multidrug resistance protein 1 (MDR1) in vesicles assay.
生化／生理作用
SOLVO Biotechnology offers NMQ as a selective substrate for the MDR1 membrane transporter.
NMQ was shown to be actively transported by human MDR1/P-gp and rat Mdr1b efflux transporters.
NMQ was shown to be actively transported by human MDR1/P-gp and rat Mdr1b efflux transporters.
Potential herb-drug interaction of shexiang baoxin pill in vitro based on drug metabolism/transporter.
Shen Z, et al.
American Journal of Translational Research, 8(12), 5545-5545 (2016)
Zhijie Shen et al.
American journal of translational research, 8(12), 5545-5556 (2017-01-13)
Many researches have proved functions of anti-oxidation, endothelial protection and pro-angiogenesis efficiency of Shexiang Baoxin Pill (SBP). This study aims to investigate potential for metabolism-based interaction on CYP450s and transporter based interaction on OATP1B1, BRCP and MDR1. Human primary hepatocytes
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