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Merck

Q1125

Sigma-Aldrich

Quinine hydrochloride dihydrate

99-101% (titration), potassium channel blocker

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About This Item

经验公式(希尔记法):
C20H24N2O2 · HCl · 2H2O
CAS号:
分子量:
396.91
EC號碼:
MDL號碼:
分類程式碼代碼:
12352210
PubChem物質ID:
NACRES:
NA.77

product name

Quinine hydrochloride dihydrate,

品質等級

溶解度

H2O: 0.25/5 g/mL, clear, colorless

抗生素活性譜

parasites

作用方式

enzyme | inhibits

SMILES 字串

O.Cl.[H][C@]1(C[C@@H]2CC[N@H]1C[C@@H]2C=C)[C@H](O)c3ccnc4ccc(OC)cc34

InChI

1S/C20H24N2O2.ClH.H2O/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;;/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;1H;1H2/t13-,14-,19-,20+;;/m0../s1

InChI 密鑰

SGVZDMWHXVXUBY-HZQSTTLBSA-N

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一般說明

Quinine is derived from the stem of cinchona (quina-quina) tree. It is an alkaloid having various applications in the field of medicine. Quinine is a basic compound with aryl amino alcohol group.

應用

Quinine hydrochloride dihydrate has been used in Drosophila larval behavioral assay. It has also been used in taste preference analysis among rats.

生化/生理作用

Quinine is widely used in the treatment of malaria. It possesses erythrocytic and gametocytocidal action against Plasmodium sp. It also serves as an analgesic drug. Upon administration, quinine is present mostly bound to α-1 acid glycoprotein in the body fluids. Quinine has the ability to cross the placenta and the blood brain barrier. It has a half-life of 11-18 hours. Tinnitus, hearing defects, nausea and headache are some of its side effects.
钾通道阻断剂。

象形圖

Health hazardExclamation mark

訊號詞

Danger

危險聲明

危險分類

Acute Tox. 4 Oral - Resp. Sens. 1 - Skin Sens. 1

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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High-NaCl perception in Drosophila melanogaster
Alves G, et al.
The Journal of Neuroscience, 34(33), 10884-10891 (2014)
The first stereoselective total synthesis of quinine
Stork G, et al.
Journal of the American Chemical Society, 123(14), 3239-3242 (2001)
Preferences of 14 rat strains for 17 taste compounds
Tordoff MG, et al.
Physiology & Behavior, 95(3), 308-332 (2008)
Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria
Achan J, et al
Malaria Journal, 10(1), 144-144 (2011)
Hu Chen et al.
Addiction biology, 25(6), e12821-e12821 (2019-08-23)
One of the most pernicious characteristics of alcohol use disorder is the compulsion to drink despite negative consequences. The insular cortex controls decision making under conditions of risk or conflict. Cortical activity is tightly controlled by inhibitory interneurons that are

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