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PZ0162

Sigma-Aldrich

PD 0325901

≥98% (HPLC)

别名:

N-[(2R)-2,3-二羟基丙氧基]-3,4-二氟-2-[(2-氟-4-碘苯)氨基]苯甲酰胺

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About This Item

经验公式（希尔记法）:
C16H14F3IN2O4
CAS号:
391210-10-9
分子量:
482.19
MDL號碼:
MFCD08435926
分類程式碼代碼:
12352200
PubChem物質ID:
329823743

品質等級

100

化驗

≥98% (HPLC)

形狀

powder

光學活性

[α]/D -1.8 to -3.5°, c = 1 mg/mL in methanol

顏色

white to off-white

溶解度

DMSO: 20 mg/mL, clear

儲存溫度

2-8°C

SMILES 字串

FC1=C(NC2=CC=C(I)C=C2F)C(C(NOC[C@H](O)CO)=O)=CC=C1F

InChI

1S/C16H14F3IN2O4/c17-11-3-2-10(16(25)22-26-7-9(24)6-23)15(14(11)19)21-13-4-1-8(20)5-12(13)18/h1-5,9,21,23-24H,6-7H2,(H,22,25)/t9-/m1/s1

InChI 密鑰

SUDAHWBOROXANE-SECBINFHSA-N

基因資訊

human ... MAP2K1(5604) , MAP2K2(5605)

應用

PD 0325901作为抑制剂，用于细胞外信号调节激酶（ERK）抑制试验，在引物诱导性多能干细胞、 RKO结直肠癌细胞系 和人胚胎干细胞（hESCs）中进行。

生化／生理作用

PD 0325901是一种有效的MKK1（MEK1）和MKK2（MEK2）抑制剂。PD 0325901对MEK1和MEK2的Ki分别为1.1和0.79nM。PD 0325901对一组27种其他激酶无活性。以25mg/kg对小鼠给药时，PD 0325901对C26肿瘤pERK的抑制率达到75％。
通过抑制丝裂原激活的蛋白激酶（MAPK），PD 0325901对胶质母细胞瘤 和黑色素瘤的肿瘤进展产生抑制生长和抗血管生成作用。

特點和優勢

《受体分类和信号转导》手册的 MAPKKK 页面有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。

其他說明

2024年CiteAb奖——成功的帕金森研究供应商(2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research)

象形圖

Skull and crossbonesHealth hazard
GHS06,GHS08

訊號詞

Danger

危險聲明

H301,H373,H413

危險分類

Acute Tox. 3 Oral - Aquatic Chronic 4 - STOT RE 2

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

从最新的版本中选择一种：

分析证书(COA)

Lot/Batch Number
021M4710V
114M4717V
044M4715V
073M4724V
110M4714V

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Sigma-Aldrich

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Cohesin exists in two variants carrying either STAG/SA1 or SA2. Here we have addressed their specific contributions to the unique spatial organization of the mouse embryonic stem cell genome, which ensures super-enhancer-dependent transcription of pluripotency factors and repression of lineage-specification genes
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The Akt pathway is a well-known promoter of tumor malignancy. Akt3 is expressed as two alternatively spliced variants, one of which lacks the key regulatory serine 472 phosphorylation site. Whereas the function of full-length Akt3 isoform (Akt3/+S472) is well-characterized, that
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