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Merck

PZ0181

Sigma-Aldrich

PD184352

≥98% (HPLC)

别名:

2-(2-氯-4-碘代苯氨基)-N-环丙基甲氧基-3,4-二氟苯甲酰胺, CI-1040

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About This Item

经验公式(希尔记法):
C17H14ClF2IN2O2
分子量:
478.66
MDL號碼:
分類程式碼代碼:
51111800
PubChem物質ID:
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

powder

顏色

white to tan

溶解度

DMSO: ≥30 mg/mL

儲存溫度

room temp

SMILES 字串

Fc1ccc(C(=O)NOCC2CC2)c(Nc3ccc(I)cc3Cl)c1F

InChI

1S/C17H14ClF2IN2O2/c18-12-7-10(21)3-6-14(12)22-16-11(4-5-13(19)15(16)20)17(24)23-25-8-9-1-2-9/h3-7,9,22H,1-2,8H2,(H,23,24)

InChI 密鑰

GFMMXOIFOQCCGU-UHFFFAOYSA-N

基因資訊

生化/生理作用

PD184352(CI-1040)是 MEK(MKK1;MAPK 激酶)和密切相关的 MKK2 的高度选择性非竞争性抑制剂。它具有抗癌活性,抑制 ERK 通路,已与其他类型的抑制剂一起用于建立胚胎干细胞系。
PD184352(CI-1040)是一种高度选择性的 MEK(MKK1;MAPK 激酶)抑制剂。

特點和優勢

《受体分类和信号转导》手册的 MAPK 页面有该化合物的介绍。如需浏览其他手册页面,请点击此处

象形圖

Environment

訊號詞

Warning

危險聲明

防範說明

危險分類

Aquatic Acute 1

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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