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S4317

Sigma-Aldrich

SB 431542 水合物

≥98% (HPLC), powder, inhibits activation of SMAD proteins

别名:

4-(5-苯并[1,3]二唑-5-基-4-吡啶-2-基-1H-咪唑-2-基)-苯甲酰胺 水合物, 4-[4-(1,3-苯并二唑-5-基)-5-(2-吡啶基)-1H-咪唑-2-基]-苯甲酰胺 水合物, 4-[4-(3,4-亚甲二氧基苯基)-5-(2-吡啶基)-1H-咪唑-2-基]-苯甲酰胺 水合物

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About This Item

经验公式（希尔记法）:
C22H16N4O3 · xH2O
CAS号:
301836-41-9
分子量:
384.39 (anhydrous basis)
MDL號碼:
MFCD11045982
分類程式碼代碼:
51111800
PubChem物質ID:
24724609
NACRES:
NA.77

product name

SB 431542 水合物, ≥98% (HPLC), powder

化驗

≥98% (HPLC)

形狀

powder

溶解度

DMSO: soluble 10 mg/mL
H2O: insoluble

起源

GlaxoSmithKline

儲存溫度

−20°C

SMILES 字串

O.NC(=O)c1ccc(cc1)-c2nc(-c3ccc4OCOc4c3)c([nH]2)-c5ccccn5

InChI

1S/C22H16N4O3.H2O/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17;/h1-11H,12H2,(H2,23,27)(H,25,26);1H2

InChI 密鑰

WQUIJVKNPYBZOF-UHFFFAOYSA-N

應用

SB-431542被用于研究结直肠肿瘤细胞中血小板衍生生长因子受体B表达与TGF-β途径激活的相关性。它被用于研究TGF-β信号传导在调节细胞外基质 和成肌细胞分化中的作用。

生化／生理作用

SB-431542可抑制TGF-β介导的SMAD蛋白活化、胶原和纤连蛋白表达、细胞增殖和细胞运动。它不抑制因血清或应激而激活的激酶，如ERK、p38或JNK。
转化生长因子-β超家族I型激活素受体样激酶（ALK）受体的有效和选择性抑制剂。

特點和優勢

该化合物由 GlaxoSmithKline开发。想要浏览其他由制药公司开发的化合物以及已批准物/候选药物清单， 请单击此处。

法律資訊

根据Glaxo­Smith­Kline协议出售，用于研究目的

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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