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产品名称
Platelet-Derived Growth Factor-AA 人, PDGF-AA, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
生物源
human
品質等級
重組細胞
expressed in E. coli
化驗
≥98% (SDS-PAGE and HPLC)
形狀
lyophilized powder
效力
1.0-3.0 ng/mL ED50
品質
endotoxin tested
分子量
28.5 kDa (containing 250 amino acid residues)
包裝
pkg of 10 μg
pkg of 50 μg
儲存條件
avoid repeated freeze/thaw cycles
技術
cell culture | mammalian: suitable
雜質
<1 EU/μg
UniProt登錄號
儲存溫度
−20°C
基因資訊
human ... PDGFRA(5154)
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一般說明
Platelet-derived growth factor (PDGF) is composed two polypeptide subunits of A and B chain. PDGF is produced by a number of cells including smooth muscle cells, endothelial cells and macrophages. The PDGF gene is highly conserved and is mapped to human chromosome 7p22.3. PDGF is structurally and functionally related to vascular endothelial growth factors.
生化／生理作用
Cell division and relocalization of pulmonary artery smooth muscle cells and fibroblasts is known to be triggered by platelet-derived growth factor (PDGF). Due to its proliferatory function, it is associated with fibroproliferative disorders such as atherosclerosis, pulmonary arterial hypertension and lung fibrosis. PDGF exists both in homo and heterodimeric forms and stimulates α and β-cell surface receptors. Vascular endothelial growth factor expression is regulated by PDGF-AA autocrine signalling and is known to promote tumor angiogenesis in vivo.
其他說明
Homodimer of the A chain of human PDGF.
外觀
Lyophilized from a sterile filtered buffered solution.
分析報告
The biological activity is measured by the dose-dependent stimulation of thymidine uptake by BALB/c 3T3 cells.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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Role of platelet-derived growth factors in physiology and medicine.
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商品
Platelet-Derived Growth Factor is the principal mitogen found in mammalian serum and is released from platelets during clot formation.
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