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品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
white to off-white
溶解度
DMSO: >10 mg/mL
儲存溫度
2-8°C
SMILES 字串
CC(C)(C)n1nc(-c2ccc(Cl)cc2)c3c(N)ncnc13
InChI
1S/C15H16ClN5/c1-15(2,3)21-14-11(13(17)18-8-19-14)12(20-21)9-4-6-10(16)7-5-9/h4-8H,1-3H3,(H2,17,18,19)
InChI 密鑰
PBBRWFOVCUAONR-UHFFFAOYSA-N
應用
PP2 已被用于:
- 分析 Src/粘着斑激酶（FAK）信号传导对 IQ 结构域 GTP酶激活蛋白 1 （IQGAP1）介导的失巢凋亡抗性的影响
- 用于 Src 抑制以研究其对非小细胞肺癌 （NSCLC） 细胞中表皮生长因子受体（EGFR） 和核因子E 2 相关因子 2（Nrf2） 磷酸化的影响
- 用于MDA-MB-231 乳腺癌细胞中 SRC的药物抑制
生化／生理作用
PP2 是非受体酪氨酸激酶（nRTK） 的Src-家族酪氨酸激酶的选择性抑制剂。它对ζ链TCR相关蛋白激酶70（ZAP-70）和 Janus激酶 2（JAK2）的选择性>10000 倍。PP2 在体外和体内有效地减少宫颈癌增殖。
特點和優勢
该化合物是激酶磷酸酶生物学研究的特色产品。 点击此处 ，发现更多特色激酶磷酸酶生物学产品。在 sigma.com/discover-bsm了解更多关于其他研究领域的生物活性小分子。
訊號詞
Danger
危險聲明
防範說明
危險分類
Acute Tox. 3 Oral
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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