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品質等級
化驗
≥98% (HPLC)
形狀
solid
儲存條件
protect from light
顏色
white to off-white
mp
185-185.9 °C (lit.)
溶解度
DMSO: >5 mg/mL
儲存溫度
2-8°C
SMILES 字串
CCOC(=O)C1=C(C)NC(=S)NC1c2cccc(O)c2
InChI
1S/C14H16N2O3S/c1-3-19-13(18)11-8(2)15-14(20)16-12(11)9-5-4-6-10(17)7-9/h4-7,12,17H,3H2,1-2H3,(H2,15,16,20)
InChI 密鑰
LOBCDGHHHHGHFA-UHFFFAOYSA-N
應用
Monastrol已被用于:
- 将MDA-MB-231细胞作为非微管靶向剂
- 作为抗肿瘤剂,治疗小鼠骨髓瘤细胞系SP 2/0,诱导细胞凋亡并阐明代谢型谷氨酸受体3(Grm3)在凋亡中的作用-作为蝶呤还原酶抑制剂在GFP转染的前鞭毛体巨噬细胞中的作用
- 用于基于流式细胞仪的生长抑制试验并评价利什曼原虫仓鼠体内模型的抗利什曼活性
生化/生理作用
Monastrol 是一种强效、细胞渗透的有丝分裂抑制剂。Monastrol 阻滞细胞的特征是单极纺锤体。该表型是通过用 IC 50 在 14μM的浓度下特异性破坏有丝分裂分子马达驱动蛋白 Eg5 而诱导的。对其他马达蛋白和微管蛋白无影响。
特點和優勢
这种化合物是凋亡研究的特色产品。点击此处发现更多特色凋亡产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
包裝
在惰性气体下包装。
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
Metabotropic glutamate receptor 3 is involved in B-cell-related tumor apoptosis
International journal of oncology, 49(4), 1469-1478 (2016)
M410, a combretastatin A4 analogue, disrupts microtubules and inhibits HIF-1 alpha in human breast cancer cells
Oncology Reports, 34(1), 334-340 (2015)
PloS one, 4(4), e5282-e5282 (2009-04-25)
Polo-like kinase-1 (Plk1) is activated before mitosis by Aurora A and its cofactor Bora. In mitosis, Bora is degraded in a manner dependent on Plk1 kinase activity and the E3 ubiquitin ligase SCF-betaTrCP. Here, we show that Plk1 is also
Scientific reports, 3, 2808-2808 (2013-10-01)
The chromosome alignment is mediated by polar ejection and poleward forces acting on the chromosome arm and kinetochores, respectively. Although components of the motile machinery such as chromokinesin have been characterized, their dynamics within the spindle is poorly understood. Here
PloS one, 8(6), e64946-e64946 (2013-07-11)
Genome-wide association (GWA) studies have described a large number of new candidate genes that contribute to of Type 2 Diabetes (T2D). In some cases, small clusters of genes are implicated, rather than a single gene, and in all cases, the
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