product name
RO-3306, ≥98% (HPLC)
化驗
≥98% (HPLC)
形狀
powder
顏色
off-white to brown
溶解度
DMSO: 5 mg/mL, clear
儲存溫度
2-8°C
SMILES 字串
O=C1N=C(NCC2=CC=CS2)S/C1=C\C3=CC4=C(C=C3)N=CC=C4
InChI
1S/C18H13N3OS2/c22-17-16(24-18(21-17)20-11-14-4-2-8-23-14)10-12-5-6-15-13(9-12)3-1-7-19-15/h1-10H,11H2,(H,20,21,22)/b16-10-
InChI 密鑰
XOLMRFUGOINFDQ-YBEGLDIGSA-N
應用
RO-3306已可用于：
- 研究CA4介导的细胞毒性在有丝分裂阻滞中的重要性
- 在细胞周期同步化中进行蛋白质组学研究
- 作为CDK1抑制剂，防止进入早期有丝分裂
生化／生理作用
CDK1（细胞周期蛋白依赖性激酶1）被认为是细胞分裂的“主要开关”，它能够维持细胞的有丝分裂状态。
RO-3306是一种选择性ATP竞争性CDK1抑制剂。 它能够抑制CDK1/cyclin B1的活性，Ki值为35 nM，它对CDK1/cyclin B1的选择性是CDK2/cyclin E的近10倍，是CDK4/cyclin D的50倍以上。RO-3306已可用于使细胞周期阻滞在G2/M期。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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商品
CDKs
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