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品質等級
化驗
≥99% (TLC)
形狀
powder
mp
300 °C (dec.)
溶解度
DMSO: soluble 10 mg/mL (may require heating)
H2O: insoluble
儲存溫度
2-8°C
SMILES 字串
COC(=O)Nc1nc2cc(ccc2[nH]1)C(=O)c3cccs3
InChI
1S/C14H11N3O3S/c1-20-14(19)17-13-15-9-5-4-8(7-10(9)16-13)12(18)11-3-2-6-21-11/h2-7H,1H3,(H2,15,16,17,19)
InChI 密鑰
KYRVNWMVYQXFEU-UHFFFAOYSA-N
基因資訊
human ... TUBB(203068)
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一般說明
Nocodazole (NZO) is an experimental benzimidazole-based agent that targets both protein kinases and microtubules. It serves as a lead compound in the quest for new colchicine binding site inhibitors (CBSIs). This co-crystallized ligand acts as a high-affinity ligand for cancer-related kinases ABL, c-KIT, BRAF, and MEK, and functions as a rapidly-reversible inhibitor of microtubule polymerization.
應用
Nocodazole has been used to induce microtubule depolymerization in mouse melanoma B16-F1 cells. It has also been used to treat A549 cells for mitotic arrest.
生化／生理作用
诺考达唑(Nocodazole)是一种抗有丝分裂剂，通过结合β−−微管蛋白，阻止两对链间二硫键之一的形成，进而抑制微管动力学、破坏有丝分裂纺锤体功能和片段化高尔基复合体来解聚微管。诺考达唑将细胞周期阻滞在G2/M期，也阻止T细胞抗原受体的磷酸化并抑制其活性。在一些正常和肿瘤细胞系中，诺考达唑刺激微管蛋白内在GTP酶活性，激活JNK/SAPK信号传导通路和诱导凋亡。诺考达唑增强CRISPR同源重组修复(HDR)效率和加强Cas9介导的编辑频率。
外觀
颜色从白色到淡黄色和粉红色
訊號詞
Warning
危險聲明
危險分類
Muta. 2 - Repr. 2
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
其他客户在看
Alessandra Pisciottani et al.
Cells, 8(7) (2019-07-10)
Abscission is the final step of cell division, mediating the physical separation of the two daughter cells. A key player in this process is the microtubule-severing enzyme spastin that localizes at the midbody where its activity is crucial to cut
Muralidharan Mani et al.
Biochimica et biophysica acta. Molecular cell research, 1866(9), 1463-1474 (2019-06-15)
The perinuclear stacks of the Golgi apparatus maintained by dynamic microtubules are essential for cell migration. Activation of Akt (protein kinase B, PKB) negatively regulates glycogen synthase kinase 3β (GSK3β)-mediated tau phosphorylation, which enhances tau binding to microtubules and microtubule
Yuanming Cheng et al.
Cell reports, 28(7), 1703-1716 (2019-08-15)
Stem cells balance cellular fates through asymmetric and symmetric divisions in order to self-renew or to generate downstream progenitors. Symmetric commitment divisions in stem cells are required for rapid regeneration during tissue damage and stress. The control of symmetric commitment remains
Therese Wilhelm et al.
Nature communications, 10(1), 3585-3585 (2019-08-10)
Replication stress, a hallmark of cancerous and pre-cancerous lesions, is linked to structural chromosomal aberrations. Recent studies demonstrated that it could also lead to numerical chromosomal instability (CIN). The mechanism, however, remains elusive. Here, we show that inducing replication stress
Shunsuke Ishii et al.
Scientific reports, 9(1), 11635-11635 (2019-08-14)
Lysosomes are largely responsible for significant degradation of intracellular and extracellular proteins via the secretory pathway, autophagy, and endocytosis. Therefore, dysregulation of lysosomal homeostasis influences diverse cellular functions. However, a straightforward and quantitative method to measure the integrity of the
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High titer lentiviral particles including beta-actin, alpha-tubulin and vimentin used for live cell analysis of cytoskeleton structure proteins.
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