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Merck

M6875

Sigma-Aldrich

2-Mercaptopurine

≥95%, crystalline

别名:

2-MP, 2-Purinethiol, 2-Thiopurine

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About This Item

经验公式(希尔记法):
C5H4N4S
CAS号:
分子量:
152.18
EC號碼:
MDL號碼:
分類程式碼代碼:
41106305
PubChem物質ID:
NACRES:
NA.51

化驗

≥95%

形狀

crystalline

顏色

yellow

溶解度

1 M NH4OH: 50 mg/mL, clear to slightly hazy, yellow to brown

SMILES 字串

[H]n1cnc2cnc(S)nc12

InChI

1S/C5H4N4S/c10-5-6-1-3-4(9-5)8-2-7-3/h1-2H,(H2,6,7,8,9,10)

InChI 密鑰

HDBQZGJWHMCXIL-UHFFFAOYSA-N

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應用

2-Mercaptopurine (2-MP), a thiopurine and analog of the anti-cancer drug 6-mercaptopurine (6-MP), has been used to study the substrate and binding specificity and kinetics of xanthine oxidase-catalyzed hydroxylation and myeloperoxidase (MPO) reactions. 2-Mercaptopurine inhibited lipopolysacharide (LPS)-dependent nitric oxide (NO) production in B cells.

象形圖

CorrosionExclamation mark

訊號詞

Danger

危險聲明

危險分類

Acute Tox. 4 Oral - Eye Dam. 1

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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U Burner et al.
FEBS letters, 443(3), 290-296 (1999-02-20)
Myeloperoxidase (MPO) is the most abundant protein in neutrophils and plays a central role in microbial killing and inflammatory tissue damage. Because most of the non-steroidal anti-inflammatory drugs and other drugs contain a thiol group, it is necessary to understand
Xi Chen et al.
Protein & cell, 10(5), 327-346 (2018-08-22)
Primitive mammalian heart transforms from a single tube to a four-chambered muscular organ during a short developmental window. We found that knocking out global microRNA by deleting Dgcr8 microprocessor in Mesp1 cardiovascular progenitor cells lead to the formation of extremely
Mohammad Amin Safari et al.
International journal of environmental research and public health, 17(18) (2020-09-18)
This study assessed the effect of swimming training on anxiety-like behaviors and corticosterone. Thirty adult male Wistar rats were randomly assigned to five study conditions: swimming training (ST); exposure to chronic mild stress (CS); exposure to chronic mild stress followed
Hemlata Tamta et al.
Biochemistry. Biokhimiia, 72(2), 170-177 (2007-03-21)
Xanthine oxidase-catalyzed hydroxylation reactions of the anticancer drug 6-mercaptopurine (6-MP) and its analog 2-mercaptopurine (2-MP) as well as 6-thioxanthine (6-TX) and 2-thioxanthine (2-TX) have been studied using UV-spectroscopy, high pressure liquid chromatography, photodiode array, and liquid chromatography-based mass spectral analysis.
S Hortelano et al.
Molecular pharmacology, 51(3), 414-421 (1997-03-01)
6-Mercaptopurine and related purine antimetabolites are used in the treatment of several B cell disorders. These drugs inhibited the proliferation of mature splenic B cells after being triggered with polyclonal mitogens. In addition to the antiproliferative effects, 6-mercaptopurine, 2-mercaptopurine, and

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