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About This Item
经验公式（希尔记法）:
C13H15Cl2NO · HCl
CAS号:
分子量:
308.63
EC號碼:
MDL號碼:
分類程式碼代碼:
12352116
PubChem物質ID:
NACRES:
NA.77
推荐产品
品質等級
化驗
≥97% (GC)
形狀
powder
溶解度
DMSO: 10 mg/mL, clear, colorless to faintly yellow
儲存溫度
2-8°C
SMILES 字串
Cl.CN(CCCOc1ccc(Cl)cc1Cl)CC#C
InChI
1S/C13H15Cl2NO.ClH/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15;/h1,5-6,10H,4,7-9H2,2H3;1H
InChI 密鑰
BBAZDLONIUABKI-UHFFFAOYSA-N
基因資訊
human ... MAOA(4128)
rat ... Maoa(29253) , Maob(25750)
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應用
N-甲基-N-炔丙基-3-(2,4-二氯苯氧基)丙胺盐酸盐作为单胺氧化酶(MAO-A)抑制剂的应用实例：
- MAO-A生化检测
- 研究其对人胎盘外植体血清素(5-HT)转运的影响
- 研究其对人前列腺癌细胞的影响作用
生化／生理作用
MAO-A 抑制剂。
特點和優勢
该化合物收录于受体分类和信号转导手册的《多巴胺和去甲肾上腺素代谢》页面。想要浏览手册的其他页面， 请单击此处。
訊號詞
Danger
危險聲明
危險分類
Acute Tox. 3 Oral
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 3
個人防護裝備
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
其他客户在看
J C Shih et al.
Journal of neural transmission. Supplementum, 52, 1-8 (1998-06-13)
MAO-A and -B are defined by their substrate and inhibitor preferences. To determine which regions of the isoenzymes confer these preferences, we have constructed six chimeric MAO enzymes by reciprocally exchanging corresponding N-terminal, C-terminal, and internal segments of MAO-A and
Tamara Maes et al.
Cancer cell, 33(3), 495-511 (2018-03-06)
The lysine-specific demethylase KDM1A is a key regulator of stem cell potential in acute myeloid leukemia (AML). ORY-1001 is a highly potent and selective KDM1A inhibitor that induces H3K4me2 accumulation on KDM1A target genes, blast differentiation, and reduction of leukemic
Toshiaki Shinka et al.
Oncology letters, 2(2), 211-215 (2011-03-01)
Prostate cancer is one of the most common tumors in males and its incidence is steadily increasing worldwide. Serotonin or 5-hydroxytryptamine (5-HT) is a well-known neurotransmitter that mediates a wide variety of physiological effects. An increase in the number of
H Inoue et al.
The Journal of pharmacology and experimental therapeutics, 291(2), 856-864 (1999-10-19)
In an attempt to provide a better understanding of the scope and limitations of animal models used in some drug development programs and to further our understanding of potential metabolic bioactivation reactions, we have undertaken studies to profile the monoamine
Melissa D'Ascenzio et al.
Journal of enzyme inhibition and medicinal chemistry, 30(6), 908-919 (2015-03-26)
Several (thiazol-2-yl)hydrazone derivatives from 2-, 3- and 4-acetylpyridine were synthesized and tested against human monoamine oxidase (hMAO) A and B enzymes. Most of them had an inhibitory effect in the low micromolar/high nanomolar range, being derivatives of 4-acetylpyridine selective hMAO-B
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