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重組細胞
expressed in baculovirus infected BTI insect cells
品質等級
形狀
liquid
enzyme activity
≥1 U/mg
包裝
vial of ~2.5 mg
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−70°C
基因資訊
human ... MAOB(4129)
一般說明
单胺氧化酶B是一种线粒体外膜黄素酶，是抗抑郁药和神经保护药的靶点。
應用
单胺氧化酶B已可用于评估年龄对人类大脑的23个不同区域的影响。 它还被用于确定人脑中单胺氧化酶的具体位置。
单胺氧化酶B活性抑制剂被用于治疗各种神经障碍，包括抑郁症。
生化／生理作用
MAO是线粒体膜的蛋白质。 这些酶可催化内生和外源胺的氧化脱氨反应。 每种亚型具有不同的底物特异性。
單位定義
犬尿胺的脱氨活性：pH 7.4、37 °C 条件下，一个单位每分钟可脱氨 1 nm 犬尿胺。
相關產品
产品编号
说明
价格
儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
其他客户在看
The effect of age on the activity and molecular properties of human brain monoamine oxidase
Fowler, C., et al.
Journal of Neural Transmission. General Section, 49, 1-20 (1980)
K N Westlund et al.
Neuroscience, 25(2), 439-456 (1988-05-01)
Monoclonal antibodies, specific for either monoamine oxidases A or B, were used to determine the localization of monoamine oxidase in the human brain. Two distinct populations of neurons were detected by immunocytochemical staining. Neurons in regions rich in catecholamines were
Aiko Ishiki et al.
Acta neuropathologica communications, 6(1), 53-53 (2018-07-01)
Recent positron emission tomography (PET) studies have demonstrated the accumulation of tau PET tracer in the affected region of progressive supranuclear palsy (PSP) cases. To confirm the binding target of radiotracer in PSP, we performed an imaging-pathology correlation study in
Structure of human monoamine oxidase B, a drug target for the treatment of neurological disorders
Binda, C., et al.
Nature Structural Biology, 9, 22-26 (2001)
Kenneth I Shulman et al.
CNS drugs, 27(10), 789-797 (2013-08-13)
This paper reviews the discovery and history of the use of irreversible monoamine oxidase (MAO) inhibitors (MAOIs) such as phenelzine, tranylcypromine and isocarboxazid, as well as the second generation selective and reversible MAOIs such as the MAO-A inhibitor, moclobemide and
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