SML0025

Safinamide mesylate salt

≥98% (HPLC)

• 别名: (S)-(+)-2-[[4-(3-Fluorobenzoxy)benzyl]amino]propanamide; (S)-2-[[4-[(3-Fluorobenzyl)oxy]benzyl]amino]propanamide; FCE-26743; PNU-151774E, NW-1015;
• 经验公式（希尔记法）: C₁₇H₁₉FN₂O₂ · xCH₄O₃S
• CAS号: 202825-46-5
• 分子量: 302.34 (free base basis)
• MDL號碼: MFCD15145475
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329825096
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 光學活性: [α]/D +9.5 to +14°, c = 1 (95% acetic acid)
• 顏色: white to tan
• 溶解度: H₂O: ≥15 mg/mL
• 儲存溫度: 2-8°C
• SMILES 字串: CS(O)(=O)=O.C[C@H](NCc1ccc(OCc2cccc(F)c2)cc1)C(N)=O
• InChI: 1S/C17H19FN2O2.CH4O3S/c1-12(17(19)21)20-10-13-5-7-16(8-6-13)22-11-14-3-2-4-15(18)9-14;1-5(2,3)4/h2-9,12,20H,10-11H2,1H3,(H2,19,21);1H3,(H,2,3,4)/t12-;/m0./s1
• InChI 密鑰: YKOCHIUQOBQIAC-YDALLXLXSA-N
• 基因資訊: human ... MAOB(4129)

说明

應用

Safinamide mesylate salt has been used as a reference drug to study its inhibitory effect on human monoamine oxidases (hMAO-A and hMAO-B).

Safinamide mesylate salt may be used in cell signaling studies.

生化／生理作用

Safinamide is a highly selective and reversible monoamine oxidase type B (MAO-B) inhibitor that increases neostriatal dopamine concentration. In addition, safinamide is voltage-dependent sodium and calcium channel blocker. It appears to bind to the batrachotoxin-sensitive site 2 of the voltage-sensitive sodium channels. Safinamide blocks N and L-type calcium channels and inhibits glutamate and aspartate release from synaptic terminals.

Safinamide mesylate prevents dopamine reuptake and is effective in the treatment of epilepsy and Parkinson′s disease.

特點和優勢

This compound is featured on the Calcium Channels and Dopamine and Norepinephrine Metabolism pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全信息

• 象形圖: GHS08,GHS07
• 訊號詞: Warning
• 危險聲明: H302,H319,H361d
• 防範說明: P202 - P264 - P270 - P301 + P312 - P305 + P351 + P338 - P308 + P313
• 危險分類: Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable