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品質等級
化驗
≥95% (HPLC)
形狀
powder
顏色
white to off-white
溶解度
H2O: ≥10 mg/mL
DMSO: ≥20 mg/mL
儲存溫度
−20°C
SMILES 字串
CCC[C@H]1OC(=O)C(=C)[C@@H]1C(O)=O
InChI
1S/C9H12O4/c1-3-4-6-7(8(10)11)5(2)9(12)13-6/h6-7H,2-4H2,1H3,(H,10,11)/t6-,7+/m1/s1
InChI 密鑰
SRQUTZJZABSZRQ-RQJHMYQMSA-N
應用
MB-3已被用作通用控制蛋白5 (GCN5)抑制剂：
- 研究其对核纤层蛋白A/C相关pY19-Cav-2-介导组蛋白H3乙酰化的影响
- 分析其对拟南芥幼苗生长的影响
- 研究其对颅面软骨细胞成熟的影响
生化／生理作用
MB-3 是一种 Gcn5 HAT（组蛋白乙酰转移酶）抑制剂；具有抗炎、抗癌作用。
MB-3可以修饰小鼠胚胎干细胞和酵母的基因表达。它通过与GCN5中的乙酰辅酶CoA口袋结合来抑制通用控制蛋白5(GCN5)的乙酰转移酶活性。
特點和優勢
这种化合物是基因调控研究的特色产品。点击此处发现更多特色基因调控产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
Hong-Bin Cai et al.
Journal of Alzheimer's disease : JAD, 77(1), 75-84 (2020-04-21)
The connection between diabetes and Alzheimer's disease (AD) is not fully determined. Hyperphosphorylation of tau protein is mediated by binding and stabilization of truncated p25 with cyclin-dependent kinase-5 (CDK5) in AD. We recently showed that diabetes-associated hyperglycemia increased the CDK5
Naomi Moris et al.
Stem cells (Dayton, Ohio), 36(12), 1828-1838 (2018-10-03)
Cell fate transitions in mammalian stem cell systems have often been associated with transcriptional heterogeneity; however, existing data have failed to establish a functional or mechanistic link between the two phenomena. Experiments in unicellular organisms support the notion that transcriptional
Hao Xu et al.
Scientific reports, 10(1), 1817-1817 (2020-02-06)
Mesenchymal stem cells (MSCs) specifically differentiate into cardiomyocytes as a potential way to reverse myocardial injury diseases, and uncovering this differentiation mechanism is immensely important. We have previously shown that histone acetylation/methylation and DNA methylation are involved in MSC differentiation
M Semer et al.
Nature chemical biology, 15(10), 992-1000 (2019-09-19)
Post-translational modifications of histone variant H2A.Z accompany gene transactivation, but its modifying enzymes still remain elusive. Here, we reveal a hitherto unknown function of human KAT2A (GCN5) as a histone acetyltransferase (HAT) of H2A.Z at the promoters of a set
Michael Tscherner et al.
Microorganisms, 7(7) (2019-07-18)
Candida species represent one of the most frequent causes of hospital-acquired infections in immunocompromised patient cohorts. Due to a very limited set of antifungals available and an increasing prevalence of drug resistance, the discovery of novel antifungal targets is essential.
商品
Epigenetic modifications are thought to occur through two key interconnected processes—DNA methylation and the covalent modification of histones.
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