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D1530

Sigma-Aldrich

1α,25-二羟基维生素D3

≥99% (HPLC)

别名:

1α,25-二羟胆钙化醇, 骨化三醇

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About This Item

经验公式（希尔记法）:
C27H44O3
CAS号:
32222-06-3
分子量:
416.64
Beilstein:
7559394
EC號碼:
250-963-8
MDL號碼:
MFCD00867079
分類程式碼代碼:
12352205
eCl@ss:
34058003
PubChem物質ID:
24893473
NACRES:
NA.79

品質等級

300

化驗

≥99% (HPLC)

形狀

solid

技術

HPLC: suitable

儲存溫度

−20°C

SMILES 字串

[H][C@@]1(CC[C@@]2([H])C(\CCC[C@]12C)=C\C=C3\C[C@@H](O)C[C@H](O)C3=C)[C@H](C)CCCC(C)(C)O

InChI

1S/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b20-10+,21-11-/t18-,22-,23-,24+,25+,27-/m1/s1

InChI 密鑰

GMRQFYUYWCNGIN-NKMMMXOESA-N

基因資訊

human ... VDR(7421)

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相关类别

生化／生理作用

在钙的吸收和沉积中维生素D3的生物活性形式。 1α,25-二羟基维生素D3对细胞分化和增殖具有广泛的作用，并可调节免疫应答和中枢神经系统功能。最近的研究表明，1α,25-二羟基维生素D3可作为抵抗包括前列腺癌和结肠癌在内数种恶性肿瘤的化学预防剂，并显示出了与其他抗癌化合物的协同作用。
胆钙化醇是维生素D3的一种失活形式，它在经历各种水平的羟基化后可形成活性的维生素D3类似物。 1α-羟基维生素D3（阿法骨化醇是一种可代谢为1,25-二羟胆钙化醇的合成类似物，它是钙吸收和沉积中维生素D3的生物活性形式。1α,25-二羟基维生素D3对细胞分化和增殖具有广泛的作用，并可调节免疫应答和中枢神经系统功能。最近的研究表明，1α,25-二羟基维生素D3可作为抵抗包括前列腺癌和结肠癌在内数种恶性肿瘤的化学预防剂，并显示出了与其他抗癌化合物的协同作用。

象形圖

Skull and crossbonesHealth hazard
GHS06,GHS08

訊號詞

Danger

危險分類

Acute Tox. 1 Oral - Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - STOT RE 1

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類（WGK）

WGK 2

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Maurizio Cutolo et al.
Vitamins and hormones, 86, 327-351 (2011-03-23)
Epidemiological evidence indicates a significant association between vitamin D deficiency and an increased incidence of autoimmune diseases. The presence of vitamin D receptors (VDRs) in the cells of the immune system and the fact that several of these cells produce
Maria Plesa et al.
Journal of asthma and allergy, 13, 249-264 (2020-09-29)
Airway fibroblasts are major contributors to the histopathological feature of airway remodeling in asthma by their implication in the cell invasiveness and profibrogenic secretory phenotype observed in subepithelial fibrosis. 1,25 Dihydroxy vitamin D3 (1,25(OH)2D3) is an important therapeutic agent that
Milos Cekic et al.
Neurobiology of aging, 32(5), 864-874 (2009-06-02)
Administration of the neurosteroid progesterone (PROG) has been shown to be beneficial in a number of brain injury models and in two recent clinical trials. Given widespread vitamin D deficiency and increasing traumatic brain injuries (TBIs) in the elderly, we
Moira Cheung et al.
The Journal of clinical endocrinology and metabolism, 98(5), E954-E961 (2013-03-28)
X-linked hypophosphatemic rickets is caused by mutations in PHEX. Even though the disease is characterized by disordered skeletal mineralization, detailed bone densitometric studies are lacking. The aim of the study was to assess volumetric bone mineral density (vBMD) in X-linked
Edwin C Y Chow et al.
Gastroenterology, 146(4), 1048-1059 (2013-12-25)
Little is known about the effects of the vitamin D receptor (VDR) on hepatic activity of human cholesterol 7α-hydroxylase (CYP7A1) and cholesterol metabolism. We studied these processes in mice in vivo and mouse and human hepatocytes. Farnesoid X receptor (Fxr)(-/-)
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Vitamin D and Prevention of Human Disease

Vitamin D2 (ergocalciferol) is naturally synthesized from ergosterol by invertebrates, fungi, and plants in response to ultraviolet B irradiation, while vitamin D3 synthesis (cholecalciferol) is uniquely initiated in the skin of vertebrates. During sun exposure, ultraviolet B photons are absorbed by 7-dehydrocholesterol, which is found within the plasma membranes of epidermal and dermal skin layers. This reaction yields an unstable derivative of 7-dehydrocholesterol, named precholecalcitrol, which rapidly rearranges to vitamin D3. Vitamin D binding protein (DBP) is a carrier protein responsible for drawing vitamin D3 from the plasma membrane into the dermal capillaries within the extracellular space.

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