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化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: 2 mg/mL, clear
儲存溫度
2-8°C
SMILES 字串
CC(C)(C)N(CC(O)COC1=CC=CC2=C1C=CN2)CC3=CC=C(C)C=C3.O=C(O)/C=C\C(O)=O
應用
SR-18292马来酸盐已作为过氧化物酶体增殖物激活受体γ共激活因子1α (PGC1α) 的抑制剂，用于研究吡格列酮对脱髓鞘轴突的保护作用。
生化／生理作用
SR-18292是一种可通过PGC-1α乙酰化作用的增强以及糖原异生基因表达的抑制而成为一种有效的特异性肝糖异生抑制剂。SR-18292可在T2D小鼠模型中降低血糖并提高肝胰岛素敏感性。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Kfir Sharabi et al.
Cell, 169(1), 148-160 (2017-03-25)
Type 2 diabetes (T2D) is a worldwide epidemic with a medical need for additional targeted therapies. Suppression of hepatic glucose production (HGP) effectively ameliorates diabetes and can be exploited for its treatment. We hypothesized that targeting PGC-1α acetylation in the liver
Simon Licht-Mayer et al.
Acta neuropathologica, 140(2), 143-167 (2020-06-24)
Axonal loss is the key pathological substrate of neurological disability in demyelinating disorders, including multiple sclerosis (MS). However, the consequences of demyelination on neuronal and axonal biology are poorly understood. The abundance of mitochondria in demyelinated axons in MS raises
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