跳转至内容
Merck
所有图片(1)

Key Documents

L4774

Sigma-Aldrich

脂多糖 来源于肠沙门氏菌 肠炎血清型

purified by ion-exchange chromatography

别名:

LPS

登录查看公司和协议定价


About This Item

MDL號碼:
分類程式碼代碼:
12352201
NACRES:
NA.25

生物源

Salmonella enterica (Serotype enteritidis)

品質等級

形狀

lyophilized powder

純化經由

ion-exchange chromatography

雜質

<1% Protein
<1% RNA

運輸包裝

ambient

儲存溫度

2-8°C

正在寻找类似产品? 访问 产品对比指南

一般說明

This product is extracted from Salmonella enteritidis and purified by ion exchange. The source strain is ATCC 13076. Lipopolysaccharide from Salmonella enteritidis is mutagenic in murine spleen cells and causes a plaque-forming response in those cells.

應用

脂多糖 (LPS) 是革兰氏阴性菌细胞壁的特征性成分。LPS 及其脂质 A 部分通过 Toll 样受体 4 (TLR4) 刺激天然免疫系统的细胞。

生化/生理作用

Lipopolysaccharides (LPS) are localized in the outer layer of the membrane and are, in noncapsulated strains, exposed on the cell surface. They contribute to the integrity of the outer membrane, and protect the cell against the action of bile salts and lipophilic antibiotics.

準備報告

The product is soluble in water (5 mg/ml) or cell culture medium (1 mg/ml) yielding a hazy, faint yellow solution. A more concentrated, though still hazy, solution (20 mg/ml) has been achieved in aqueous saline after vortexing and warming to 70-80 oC. Lipopolysaccharides are molecules that form micelles in every solvent. Hazy solutions are observed in water and phosphate buffered saline. Organic solvents do not give clearer solutions. Methanol yields a turbid suspension with floaters, while water yields a homogeneously hazy solution.

其他說明

To gain a comprehensive understanding of our extensive range of Lipopolysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ (Lot或Batch)字后找到。

已有该产品?

在文件库中查找您最近购买产品的文档。

访问文档库

Yelena Y Grinberg et al.
PloS one, 6(4), e19294-e19294 (2011-05-05)
Spreading depression (SD) is thought to cause migraine aura, and perhaps migraine, and includes a transient loss of synaptic activity preceded and followed by increased neuronal excitability. Activated microglia influence neuronal activity and play an important role in homeostatic synaptic
Basilia Zingarelli et al.
Immunology, 124(1), 51-57 (2007-11-22)
Peroxisome proliferator activated receptor-gamma (PPARgamma) has been reported to exert anti-inflammatory properties in endotoxic shock and sepsis. One phenomenon that alters the inflammatory response to endotoxin [lipopolysaccharide (LPS)] is endotoxin tolerance, which is caused by previous exposure to endotoxin. Here
A Zarbock et al.
British journal of pharmacology, 155(3), 357-364 (2008-07-01)
Acute lung injury (ALI) remains a major challenge in critical care medicine. Both neutrophils and chemokines have been proposed as key components in the development of ALI. The main chemokine receptor on neutrophils is CXCR2, which regulates neutrophil recruitment and
Jörg Reutershan et al.
European journal of immunology, 39(6), 1597-1607 (2009-06-06)
The Duffy antigen receptor for chemokines (DARC) has a high affinity for CC and CXC chemokines. However, it lacks the ability to induce cell responses that are typical for classical chemokine receptors. The role of DARC in inflammatory conditions remains
Guangming Ren et al.
The EMBO journal, 38(6) (2019-02-23)
Deubiquitination of NLRP3 has been suggested to contribute to inflammasome activation, but the roles and molecular mechanisms are still unclear. We here demonstrate that ABRO1, a subunit of the BRISC deubiquitinase complex, is necessary for optimal NLRP3-ASC complex formation, ASC

我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门