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Key Documents

L3012

Sigma-Aldrich

脂多糖 来源于大肠杆菌 0111:B4

purified by gel-filtration chromatography

别名:

LPS

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About This Item

EC號碼:
MDL號碼:
分類程式碼代碼:
12352201
NACRES:
NA.25

生物源

Escherichia coli (O111:B4)

品質等級

形狀

lyophilized powder

純化經由

gel-filtration chromatography

雜質

<1% Protein

顏色

white to faint yellow

溶解度

water: soluble

運輸包裝

ambient

儲存溫度

2-8°C

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一般說明

该产品是从E. coli血清型 O111:B4中提取,胶过滤纯化。来源菌株由私人提供。该LPS血清型已用于刺激B细胞并诱导人肝细胞的NOS。

應用

脂多糖(LPS)是革兰氏阴性菌细胞壁的特征组分。LPS及其脂质A部分可通过能够识别常见的病原体相关分子模式(PAMP)的Toll样受体蛋白家族成员Toll样受体4(TLR4)刺激先天性免疫系统细胞。

生化/生理作用

脂多糖(LPS)位于膜的外层,并且暴露在无包膜菌株的细胞表面。它们有助于维持外层膜的完整性,并保护细胞免受胆汁盐和亲脂性抗生素的破坏。

準備報告

本品溶于水(5 mg/ml)或细胞培养基(1 mg/ml),得到浑浊的淡黄色溶液。以中更为浓缩但仍然模糊的溶液(20 mg/ml)可形成于涡旋并升温至70-80oC后。脂多糖是在每种溶剂中都形成胶束的分子。在水和磷酸盐缓冲液中都能观察到模糊的溶液。有机溶剂也不会产生更为清澈的溶液。甲醇可产生具有漂浮物的混浊悬浮液,而水则能产生均匀模糊的溶液。

其他說明

为了全面了解我们针对客户研究提供的各种脂多糖产品,建议您访问我们的碳水化合物分类页面。

象形圖

Skull and crossbones

訊號詞

Danger

危險聲明

危險分類

Acute Tox. 2 Oral

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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