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Merck
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Key Documents

I0516

Sigma-Aldrich

胰岛素 溶液 来源于牛胰腺

10 mg/mL insulin in 25  mM HEPES, pH 8.2, BioReagent, sterile-filtered, suitable for cell culture

别名:

Bovine insulin, Cell culture grade insulin

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About This Item

CAS号:
11070-73-8
MDL號碼:
MFCD00131380
分類程式碼代碼:
12352209
NACRES:
NA.77

無菌

sterile-filtered

品質等級

400

產品線

BioReagent

形狀

solution

濃度

10 mg/mL insulin in 25  mM HEPES, pH 8.2

技術

cell culture | mammalian: suitable
single cell analysis: suitable

雜質

endotoxin, tested

pH值

7.9-8.5

UniProt登錄號

P01317

運輸包裝

ambient

儲存溫度

2-8°C

InChI

1S/2C97H151N25O34S4/c2*1-12-46(10)77(120-72(131)35-98)96(154)122-76(45(8)9)94(152)107-55(24-28-74(134)135)79(137)104-53(22-26-69(100)128)82(140)116-66(40-159)93(151)118-64(38-157)90(148)103-47(11)78(136)114-63(37-124)89(147)121-75(44(6)7)95(153)119-67(41-160)92(150)115-62(36-123)88(146)109-57(30-43(4)5)84(142)110-58(31-48-13-17-50(125)18-14-48)85(143)105-52(21-25-68(99)127)80(138)108-56(29-42(2)3)83(141)106-54(23-27-73(132)133)81(139)112-60(33-70(101)129)87(145)111-59(32-49-15-19-51(126)20-16-49)86(144)117-65(39-158)91(149)113-61(97(155)156)34-71(102)130/h2*13-20,42-47,52-67,75-77,123-126,157-160H,12,21-41,98H2,1-11H3,(H2,99,127)(H2,100,128)(H2,101,129)(H2,102,130)(H,103,148)(H,104,137)(H,105,143)(H,106,141)(H,107,152)(H,108,138)(H,109,146)(H,110,142)(H,111,145)(H,112,139)(H,113,149)(H,114,136)(H,115,150)(H,116,140)(H,117,144)(H,118,151)(H,119,153)(H,120,131)(H,121,147)(H,122,154)(H,132,133)(H,134,135)(H,155,156)/t2*46-,47-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,75-,76-,77-/m00/s1

InChI 密鑰

XYPANFGXFLOTDK-CJLNJPJHSA-N

基因資訊

bovine ... INS(280829)
cow ... INS(280829)

相关类别

應用

牛胰腺胰岛素溶液已用于：
  • 研究外源胰岛素对发育期肉牛血浆葡萄糖、胰岛素、胰岛素样生长因子 I（IGF-I）和孕酮（P4）浓度的影响
  • 利用原代人滋养层细胞和胎盘绒毛外植体研究妊娠并发症期间胎盘的胰岛素反应性
  • 研究胰岛素受体信号通路对新生小鼠海马神经元树突棘密度的影响

生化／生理作用

胰岛素是一种重要的降糖激素，它的不足会导致 2 型糖尿病患者出现高血糖。
由胰岛β-细胞所产生的二链多肽激素。其分子量为~5800 Da。α链和β链是由两个链间二硫键所连接的。α链含有一个链间二硫键。胰岛素可调节细胞对葡萄糖、氨基酸和脂肪酸的摄取、利用和储存，并抑制糖原、蛋白质和脂肪的分解。

外觀

2-8 °C保存

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儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類（WGK）

WGK 2

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves

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