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91077C

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重组人胰岛素

for research or for further manufacturing use, dry powder

别名:

胰岛素 钠盐 人, 重组胰岛素

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About This Item

CAS号:
11061-68-0
EC號碼:
234-279-7
MDL號碼:
MFCD00131380
分類程式碼代碼:
41116107
NACRES:
NA.77

品質等級

300

形狀

dry powder

效力

≥27.5 units per mg

技術

cell culture | mammalian: suitable

雜質

≤1.0 EU/mL endotoxin

溶解度

water: 10 mg/mL (pH 2.0—2.5)

UniProt登錄號

P01308

運輸包裝

ambient

儲存溫度

−20°C

InChI 密鑰

PBGKTOXHQIOBKM-FHFVDXKLSA-N

基因資訊

human ... INS(3630)

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相关类别

一般說明

重组人胰岛素（rHu）在功能和结构上与天然人序列相同。由两个多肽链组成的激素，rHu 胰岛素的 A 链（21 个氨基酸）和 B 链（30 个氨基酸）通过半胱氨酸残基之间的二硫键共价连接。这种经基因工程改造的人胰岛素是全序列分子，通过重组 DNA 技术在面包酵母中生产。

應用

无血清培养基补充剂（如胰岛素）对于常用哺乳动物细胞系的长期生长至关重要。当培养基中缺少胰岛素时，细胞形态和生长速度可能会受到干扰。
  • 重组人胰岛素已用在培养基中的间充质干细胞的成脂诱导。
  • 它已被用作气道上皮细胞的细胞培养基中的补充剂。
  • 它已用于细胞分化、GLUT4（4 型葡萄糖转运蛋白）易位测定的培养基中，并通过表面等离振子共振研究胰岛素与胰岛素受体的相互作用。

生化／生理作用

由胰岛β-细胞所产生的二链多肽激素。其分子量为~5800 Da。α链和β链是由两个链间二硫键所连接的。α链含有一个链间二硫键。胰岛素可调节细胞对葡萄糖、氨基酸和脂肪酸的摄取、利用和储存，并抑制糖原、蛋白质和脂肪的分解。

其他說明

InChI：1S/C257H383N65O77S6/c1-29-131(23)205(313-193(339)104-259)252(393)317-204(130(21)22)248(389)288-159(75-82-200(349)350)217(358)282-156(71-78-189(263)335)221(362)308-183-116-403-404-117-184-243(384)305-178(111-324)240(381)294-162(88-123(7)8)225(366)295-168(95-140-53-61-146(329)62-54-140)228(369)283-154(69-76-187(261)333)218(359)290-161(87-122(5)6)223(364)285-158(74-81-199(347)348)220(361)302-174(101-190(264)336)235(376)298-170(97-142-57-65-148(331)66-58-142)231(372)309-182(242(383)304-176(255(396)397)103-192(266)338)115-402-400-113-180(307-226(367)163(89-124(9)10)291-232(373)172(99-144-105-269-119-275-144)300-219(360)155(70-77-188(262)334)284-234(375)175(102-191(265)337)303-249(390)201(127(15)16)314-211(352)150(260)92-137-44-34-31-35-45-137)213(354)274-109-196(342)280-177(110-323)239(380)301-173(100-145-106-270-120-276-145)233(374)293-165(91-126(13)14)237(378)315-202(128(17)18)247(388)287-157(73-80-198(345)346)215(356)277-133(25)210(351)289-160(86-121(3)4)224(365)296-169(96-141-55-63-147(330)64-56-141)229(370)292-164(90-125(11)12)236(377)316-203(129(19)20)250(391)311-181(114-401-405-118-185(310-244(183)385)245(386)319-207(134(26)326)253(394)306-179(112-325)241(382)318-206(132(24)30-2)251(392)312-184)214(355)273-107-194(340)278-153(72-79-197(343)344)216(357)281-151(51-42-84-271-257(267)268)212(353)272-108-195(341)279-166(93-138-46-36-32-37-47-138)227(368)297-167(94-139-48-38-33-39-49-139)230(371)299-171(98-143-59-67-149(332)68-60-143)238(379)320-208(135(27)327)254(395)322-85-43-52-186(322)246(387)286-152(50-40-41-83-258)222(363)321-209(136(28)328)256(398)399/h31-39,44-49,53-68,105-106,119-136,150-186,201-209,323-332H,29-30,40-43,50-52,69-104,107-118,258-260H2,1-28H3,(H2,261,333)(H2,262,334)(H2,263,335)(H2,264,336)(H2,265,337)(H2,266,338)(H,269,275)(H,270,276)(H,272,353)(H,273,355)(H,274,354)(H,277,356)(H,278,340)(H,279,341)(H,280,342)(H,281,357)(H,282,358)(H,283,369)(H,284,375)(H,285,364)(H,286,387)(H,287,388)(H,288,389)(H,289,351)(H,290,359)(H,291,373)(H,292,370)(H,293,374)(H,294,381)(H,295,366)(H,296,365)(H,297,368)(H,298,376)(H,299,371)(H,300,360)(H,301,380)(H,302,361)(H,303,390)(H,304,383)(H,305,384)(H,306,394)(H,307,367)(H,308,362)(H,309,372)(H,310,385)(H,311,391)(H,312,392)(H,313,339)(H,314,352)(H,315,378)(H,316,377)(H,317,393)(H,318,382)(H,319,386)(H,320,379)(H,321,363)(H,343,344)(H,345,346)(H,347,348)(H,349,350)(H,396,397)(H,398,399)(H4,267,268,271)
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产品编号
说明
价格

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

nwg

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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