所有图片(4)
About This Item
经验公式（希尔记法）:
C254H377N65O75S6
CAS号:
分子量:
5733.49
EC號碼:
MDL號碼:
分類程式碼代碼:
12352209
NACRES:
NA.77
推荐产品
等級
Hybri-Max™
品質等級
形狀
powder
效力
≥20 USP units per mg (dry basis)
技術
cell culture | hybridoma: suitable
雜質
endotoxin, tested
溶解度
acidified water, pH 2.0: 2 mg/mL
正離子痕跡
Zn: ≤1.0% (dry basis)
UniProt登錄號
運輸包裝
ambient
儲存溫度
−20°C
InChI 密鑰
IXIBAKNTJSCKJM-BUBXBXGNSA-N
基因資訊
bovine ... INS(280829)
cow ... INS(280829)
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一般說明
The insulin gene is mapped to human chromosome 11p15.5.
應用
Insulin from bovine pancreas has been used in endometrium cell culture. It has also been used to perform insulin tolerance test and to study the effect of protein undernutrition in laying hens.
Insulin from bovine pancreas was used during experimental design and treatments. Experimental animals (like cow) were infused with bovine insulin to decrease blood glucose to a constant level.
生化／生理作用
Abnormal insulin secretion or function leads to diabetes mellitus, obesity and other carbohydrate metabolism disorders. The biological effects of insulin are mediated by insulin receptor (glycoprotein) and it integrates major signaling pathways.
由胰岛β-细胞所产生的二链多肽激素。其分子量为~5800 Da。α链和β链是由两个链间二硫键所连接的。α链含有一个链间二硫键。胰岛素可调节细胞对葡萄糖、氨基酸和脂肪酸的摄取、利用和储存，并抑制糖原、蛋白质和脂肪的分解。
其他說明
InChI: 1S/C254H377N65O75S6/c1-29-131(24)205(312-192(334)103-256)250(389)317-204(130(22)23)246(385)287-158(74-81-199(344)345)216(355)281-155(70-77-188(260)330)220(359)307-183-116-399-400-117-184-242(381)305-177(110-321)238(377)293-161(87-122(6)7)223(362)294-167(94-139-52-60-145(324)61-53-139)226(365)282-153(68-75-186(258)328)217(356)289-160(86-121(4)5)221(360)284-157(73-80-198(342)343)219(358)301-173(100-189(261)331)233(372)297-169(96-141-56-64-147(326)65-57-141)229(368)308-182(241(380)303-175(253(393)394)102-191(263)333)115-398-396-113-180(212(351)270-106-193(335)277-152(71-78-196(338)339)215(354)280-150(50-41-83-268-254(264)265)210(349)269-107-194(336)278-165(92-137-45-35-31-36-46-137)225(364)296-166(93-138-47-37-32-38-48-138)228(367)298-170(97-142-58-66-148(327)67-59-142)236(375)318-206(135(28)323)251(390)319-84-42-51-185(319)244(383)285-151(49-39-40-82-255)213(352)276-134(27)252(391)392)310-248(387)202(128(18)19)315-234(373)163(89-124(10)11)291-227(366)168(95-140-54-62-146(325)63-55-140)295-222(361)159(85-120(2)3)288-207(346)132(25)274-214(353)156(72-79-197(340)341)286-245(384)201(127(16)17)314-235(374)164(90-125(12)13)292-231(370)172(99-144-105-267-119-273-144)300-237(376)176(109-320)279-195(337)108-271-211(350)179(112-395-397-114-181(309-243(183)382)240(379)275-133(26)208(347)304-178(111-322)239(378)316-203(129(20)21)249(388)311-184)306-224(363)162(88-123(8)9)290-230(369)171(98-143-104-266-118-272-143)299-218(357)154(69-76-187(259)329)283-232(371)174(101-190(262)332)302-247(386)200(126(14)15)313-209(348)149(257)91-136-43-33-30-34-44-136/h30-38,43-48,52-67,104-105,118-135,149-185,200-206,320-327H,29,39-42,49-51,68-103,106-117,255-257H2,1-28H3,(H2,258,328)(H2,259,329)(H2,260,330)(H2,261,331)(H2,262,332)(H2,263,333)(H,266,272)(H,267,273)(H,269,349)(H,270,351)(H,271,350)(H,274,353)(H,275,379)(H,276,352)(H,277,335)(H,278,336)(H,279,337)(H,280,354)(H,281,355)(H,282,365)(H,283,371)(H,284,360)(H,285,383)(H,286,384)(H,287,385)(H,288,346)(H,289,356)(H,290,369)(H,291,366)(H,292,370)(H,293,377)(H,294,362)(H,295,361)(H,296,364)(H,297,372)(H,298,367)(H,299,357)(H,300,376)(H,301,358)(H,302,386)(H,303,380)(H,304,347)(H,305,381)(H,306,363)(H,307,359)(H,308,368)(H,309,382)(H,310,387)(H,311,388)(H,312,334)(H,313,348)(H,314,374)(H,315,373)(H,316,378)(H,317,389)(H,318,375)(H,338,339)(H,340,341)(H,342,343)(H,344,345)(H,391,392)(H,393,394)(H4,264,265,268)/t131-,132-,133-,134-,135+,149-,150-,151-,152-,153-,154-,155-,156-,157-,158-,159-,160-,161-,162-,163-,164-,165-,166-,167-,168-,169-,170-,171-,172-,173-,174-,175-,176-,177-,178-,179-,180-,181-,182-,183-,184-,185-,200-,201-,202-,203-,204-,205-,206-/m0/s1
法律資訊
Hybri-Max is a trademark of Sigma-Aldrich Co. LLC
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
其他客户在看
Effects of nutritional programing on growth and metabolism caused by albumen removal in an avian model
Willems E, et al.
The Journal of Endocrinology, 225(2), 89-100 (2015)
Expression of VEGF and its receptors in the bovine endometrium throughout the estrous cycle: effects of VEGF on prostaglandin production in endometrial cells
Tasak Y, et al.
Journal of Reproduction and Development, 56(2), 223-229 (2010)
M C M B Vernay et al.
Journal of dairy science, 95(5), 2540-2549 (2012-05-01)
The metabolic load during periods of high milk production in dairy cows causes a variety of changes of metabolite blood concentrations including dramatically decreased glucose levels. These changes supposedly impair the immune system. The goal of this study was, therefore
Expression of glucocorticoid receptor alpha and its regulation in the bovine endometrium: Possible role in cyclic prostaglandin F2alpha production
Kuse M, et al.
Journal of Reproduction and Development, 59(4), 346-352 (2013)
Human longevity and 11p15. 5: a study in 1321 centenarians
Lescai F, et al.
European Journal of Human Genetics, 17(11), 1515-1515 (2009)
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