H0786

Heregulin-β, EGF Domain human

≥80% (SDS-PAGE), recombinant, expressed in E. coli, buffered aqueous glycerol solution

• 别名: HRG-β
• MDL號碼: MFCD01867052
• 分類程式碼代碼: 12352202
• NACRES: NA.32

属性

• 生物源: human
• 品質等級: 200
• 重組細胞: expressed in E. coli
• 化驗: ≥80% (SDS-PAGE)
• 形狀: buffered aqueous glycerol solution
• 分子量: 185 kDa
• 包裝: pkg of 100 μg
• 儲存條件: avoid repeated freeze/thaw cycles
• UniProt登錄號: Q02297
• 運輸包裝: dry ice
• 儲存溫度: −20°C
• 基因資訊: human ... NRG1(3084)

说明

一般說明

Truncated human sequence (amino acids 178-241) corresponding to the EGF domain and purified as a GST-fusion protein, cleaved with thrombin.

生化／生理作用

Growth factor ligand for ErbB3 and ErbB4 receptor tyrosine kinases.

Growth factor ligand for ErbB3 and ErbB4 receptor tyrosine kinases. The binding of HRG results in receptor dimerization and receptor trans-autophosphorylation. The phosphorylated receptors recruit cellular signaling proteins, initiating signaling pathways.

外觀

Solution in phosphate buffered saline containing 30% glycerol.

分析報告

Stimulates tyrosine phosphorylation of the ErbB-3/HER-3 receptor.

The biological activity is measured by its ability to activate the c-ErbB3/HER-3 receptor in treated MCF-7 cells.

安全信息

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable