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Merck

C9012

Sigma-Aldrich

双环己酮草酰二腙

≥95% purity (TLC), powder

别名:

Cuprizon, 新铜试剂, 草酰双(环己基亚肼)

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About This Item

经验公式(希尔记法):
C14H22N4O2
CAS号:
分子量:
278.35
Beilstein:
2388004
EC號碼:
MDL號碼:
分類程式碼代碼:
12171500
PubChem物質ID:
NACRES:
NA.47

product name

双环己酮草酰二腙, ≥95% (TLC)

品質等級

化驗

≥95% (TLC)

形狀

powder

技術

titration: suitable

顏色

white/clear to off-white

mp

210-214 °C (lit.)

溶解度

acetic acid: 50 mg/mL, colorless to very faintly brown

應用

diagnostic assay manufacturing
hematology
histology

儲存溫度

2-8°C

SMILES 字串

O=C(N\N=C1\CCCCC1)C(=O)N\N=C2/CCCCC2

InChI

1S/C14H22N4O2/c19-13(17-15-11-7-3-1-4-8-11)14(20)18-16-12-9-5-2-6-10-12/h1-10H2,(H,17,19)(H,18,20)

InChI 密鑰

DSRJIHMZAQEUJV-UHFFFAOYSA-N

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應用

  • 双(环己酮)草二腙(草酸双)已被用于小鼠研究 NG2(神经/胶质抗原 2)蛋白聚糖对毒性引起的脱髓鞘的影响。
  • 已用于诱导小鼠脱髓鞘。
  • 已被用于研究草酸双诱导的小鼠胼胝体脱髓鞘和髓鞘再生。

生化/生理作用

双(环己酮)草二腙(草酸双)是铜螯合剂。它导致少突胶质细胞死亡,从而导致脱髓鞘、星形胶质细胞增生和小胶质细胞活化。草酸双被广泛用于研究胼胝体线粒体功能障碍相关的原发性脱髓鞘和髓鞘再生。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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Cortical demyelination is prominent in the murine cuprizone model and is strain-dependent.
Skripuletz T, et al.
The American Journal of Pathology, 172, 1053-1061 (2008)
Demyelination and remyelination in anatomically distinct regions of the corpus callosum following cuprizone intoxication.
Steelman AJ, et al.
Neuroscience Research, 72, 32-42 (2012)
Recovery from Toxic-Induced Demyelination Does Not Require the NG2 Proteoglycan.
Stefanie Albrecht et al.
PloS one, 11(10), e0163841-e0163841 (2016-10-19)
Galanin transgenic mice with elevated circulating galanin levels alleviate demyelination in a cuprizone-induced MS mouse model.
Zhang L, et al.
PLoS ONE, 7, e33901-e33901 (2012)
Yukie Hirahara et al.
Glia, 61(3), 420-431 (2013-01-03)
Estrogen exerts neuroprotective and promyelinating actions. The therapeutic effect has been shown in animal models of multiple sclerosis, in which the myelin sheath is specifically destroyed in the central nervous system. However, it remains unproven whether estrogen is directly involved

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