化驗
≥98% (HPLC)
形狀
powder
反應適用性
reagent type: ligand
顏色
white to beige
溶解度
DMSO: 2 mg/mL, clear
儲存溫度
2-8°C
SMILES 字串
O=C1N(C2CCC(NC2=O)=O)CC3=C1C=CC=C3N
InChI
1S/C13H13N3O3/c14-9-3-1-2-7-8(9)6-16(13(7)19)10-4-5-11(17)15-12(10)18/h1-3,10H,4-6,14H2,(H,15,17,18)
InChI 密鑰
GOTYRUGSSMKFNF-UHFFFAOYSA-N
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生化／生理作用
来那度胺，沙利度胺的一种衍生物，是经批准可用于治疗多发性骨髓瘤的一种免疫调节剂。显然，来那度胺是泛素E3连接酶cereblon的一种配体，可诱导该酶降解Ikaros转录因子IKAROS家族锌指1（IKZF1）和IKZF3。来那度胺具有多效抗肿瘤作用。它可用于治疗5q缺失相关骨髓增生异常综合症（del(5q)-MDS）。
訊號詞
Warning
危險聲明
危險分類
Repr. 2 - STOT RE 2
標靶器官
Blood
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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Thalidomide and its derivatives, lenalidomide and pomalidomide, are immune modulatory drugs (IMiDs) used in the treatment of haematologic malignancies. IMiDs bind CRBN, the substrate receptor of the CUL4-RBX1-DDB1-CRBN (also known as CRL4(CRBN)) E3 ubiquitin ligase, and inhibit ubiquitination of endogenous
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