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A3650

Sigma-Aldrich

阿米卡星 水合物

aminoglycoside antibiotic

别名:

N 1 - [(S)-4-氨基-2-羟基丁酰基] 卡那霉素 A

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About This Item

经验公式（希尔记法）:
C22H43N5O13 · xH2O
CAS号:
1257517-67-1
分子量:
585.60 (anhydrous basis)
Beilstein:
1445422
EC號碼:
253-538-5
MDL號碼:
MFCD11045969
分類程式碼代碼:
51281632
PubChem物質ID:
24890796
NACRES:
NA.85

生物源

synthetic

品質等級

200

形狀

powder

顏色

white to almost white

抗生素活性譜

Gram-negative bacteria
mycobacteria

作用方式

protein synthesis | interferes

儲存溫度

2-8°C

SMILES 字串

O.NCC[C@H](O)C(=O)N[C@@H]1C[C@H](N)[C@@H](O[C@H]2O[C@H](CN)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O

InChI

1S/C22H43N5O13.H2O/c23-2-1-8(29)20(36)27-7-3-6(25)18(39-22-16(34)15(33)13(31)9(4-24)37-22)17(35)19(7)40-21-14(32)11(26)12(30)10(5-28)38-21;/h6-19,21-22,28-35H,1-5,23-26H2,(H,27,36);1H2/t6-,7+,8-,9+,10+,11-,12+,13+,14+,15-,16+,17-,18+,19-,21+,22+;/m0./s1

InChI 密鑰

DTSOZYYWEZJFSS-XTHCGPPUSA-N

一般說明

化学结构：氨基糖苷类

應用

阿米卡星水合物用于对诸如 结核分枝杆菌 和 嗜艾利希体 等微生物的抗菌敏感性研究。

生化／生理作用

阿米卡星通过与 30S 核糖体亚基结合，诱导 mRNA 误读，从而抑制细菌蛋白质合成。干扰 tRNA 从 A 位点到 P 位点的移位。

包裝

5G

其他說明

保存于密闭容器内，置于干燥通风处。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 2

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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H W Horowitz et al.
Antimicrobial agents and chemotherapy, 45(3), 786-788 (2001-02-22)
Human granulocytic ehrlichiosis is a recently described disease caused by an obligate intracellular gram-negative organism recently named Ehrlichia phagocytophila. To expand our knowledge of the susceptibility of E. phagocytophila, we tested six New York State isolates for susceptibility to 12
G J Alangaden et al.
Antimicrobial agents and chemotherapy, 42(5), 1295-1297 (1998-05-21)
An A1400G mutation of the rrs gene was identified in Mycobacterium tuberculosis (MTB) strain ATCC 35827 and in 13 MTB clinical isolates resistant to amikacin-kanamycin (MICs, >128 microg/ml). High-level cross-resistance may result from such a mutation since MTB has a
M P Goren et al.
The Pediatric infectious disease journal, 8(5), 278-282 (1989-05-01)
A three-drug antibiotic regimen including vancomycin and amikacin has been recommended as effective treatment in clinical settings in which Gram-positive bacteremias are a serious problem. To determine if vancomycin potentiates the tubular proteinuria associated with amikacin therapy, we studied febrile
P Van der Auwera
The Journal of antimicrobial chemotherapy, 27 Suppl C, 63-71 (1991-05-01)
The pharmacokinetic parameters of amikacin given once daily were compared to those of amikacin given bd at different daily dosages. In adult patients, 'peak' serum concentrations (30 min after 30 min infusion) were linearly proportional to the dose given with
Amikacin.
R D Meyer
Annals of internal medicine, 95(3), 328-332 (1981-09-01)
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