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Merck
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Key Documents

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A2324

Sigma-Aldrich

阿米卡星 硫酸盐

aminoglycoside antibiotic

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About This Item

CAS号:
149022-22-0
MDL號碼:
MFCD00167477
分類程式碼代碼:
41116107
PubChem物質ID:
24890648
NACRES:
NA.85

生物源

synthetic

品質等級

200

形狀

powder

濃度

691-806 μg/mg (dry)

顏色

white to off-white

抗生素活性譜

Gram-negative bacteria
Gram-positive bacteria
mycobacteria

作用方式

protein synthesis | interferes

儲存溫度

2-8°C

SMILES 字串

OS(O)(=O)=O.NCC[C@@H](O)C(=O)N[C@@H]1C[C@H](N)[C@@H](O[C@H]2O[C@H](CN)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O

InChI

1S/C22H43N5O13.H2O4S/c23-2-1-8(29)20(36)27-7-3-6(25)18(39-22-16(34)15(33)13(31)9(4-24)37-22)17(35)19(7)40-21-14(32)11(26)12(30)10(5-28)38-21;1-5(2,3)4/h6-19,21-22,28-35H,1-5,23-26H2,(H,27,36);(H2,1,2,3,4)/t6-,7+,8+,9+,10+,11-,12+,13+,14+,15-,16+,17-,18+,19-,21+,22+;/m0./s1

InChI 密鑰

HIBICIOPDUTNRR-BOEHXBESSA-N

相关类别

一般說明

化学结构：氨基糖苷类

應用

阿米卡星是一种氨基糖苷类抗生素，常用于治疗耐药性分枝杆菌 。 它被用于研究抗生素的生物体定向以及耐药性 。

生化／生理作用

阿米卡星通过与30S核糖体亚基结合并诱导mRNA误读来防止细菌蛋白质合成。
抗菌谱： 革兰氏阴性和革兰氏阳性菌。

其他說明

氨基糖苷类抗生素。 卡那霉素的衍生物。
保存于密闭容器内，置于干燥通风处。

品質

阿米卡星：硫酸盐比例为1:1.8

象形圖

Exclamation mark
GHS07

訊號詞

Warning

危險聲明

H317

危險分類

Skin Sens. 1

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 2

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

分析证书(COA)

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Justin R Lenhard et al.
Diagnostic microbiology and infectious disease, 98(1), 115080-115080 (2020-07-04)
The objective of this study was to utilize a co-culture hollow-fiber infection model (HFIM) to characterize the interplay between a small, difficult-to-detect, New Delhi metallo-β-lactamase-producing Klebsiella pneumoniae (NDM-Kp) minor population and a larger K. pneumoniae carbapenemase (KPC)-producing K. pneumoniae population
A M Lovering et al.
The Journal of antimicrobial chemotherapy, 43(5), 719-721 (1999-06-26)
Antibiotic-free human serum was spiked with known concentrations of liposomal amikacin and assayed on the Abbott TDx System, using polarization fluoroimmuno assay (PFIA) kits from Abbott Laboratories, Oxis and Sigma. Although all three kits gave a linear response, the Abbott
Luiz Fernando Feres et al.
Animal reproduction science, 193, 165-170 (2018-04-22)
The aim of the present study was to evaluate the likelihood of pregnancy of in vitro-produced (IVP) embryos from batches with distinct relative efficiencies. Data were retrospectively analyzed from 605 transvaginal ultrasonic-guided follicle aspiration sessions (OPU) followed by in vitro
Lejla Imamovic et al.
Cell, 172(1-2), 121-134 (2018-01-09)
Chronic Pseudomonas aeruginosa infections evade antibiotic therapy and are associated with mortality in cystic fibrosis (CF) patients. We find that in vitro resistance evolution of P. aeruginosa toward clinically relevant antibiotics leads to phenotypic convergence toward distinct states. These states are associated
Thierry Christophe et al.
PLoS pathogens, 5(10), e1000645-e1000645 (2009-10-31)
A critical feature of Mycobacterium tuberculosis, the causative agent of human tuberculosis (TB), is its ability to survive and multiply within macrophages, making these host cells an ideal niche for persisting microbes. Killing the intracellular tubercle bacilli is a key

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