跳转至内容
Merck
所有图片(1)

Key Documents

C4142

Sigma-Aldrich

硫酸卡普霉素 来源于缠绕链霉菌

antibacterial peptide

登录查看公司和协议定价
所有图片(1)

About This Item

CAS号:
1405-37-4
EC號碼:
215-776-8
MDL號碼:
MFCD00079032
分類程式碼代碼:
51281628
PubChem物質ID:
24892668
NACRES:
NA.85

品質等級

200

形狀

powder

抗生素活性譜

Gram-negative bacteria
Gram-positive bacteria
mycobacteria

作用方式

DNA synthesis | interferes

儲存溫度

−20°C

SMILES 字串

OS(O)(=O)=O.NCCC[C@H](N)C(=O)NC[C@H]1NC(=O)[C@H](CO)NC(=O)[C@H](N)CNC(=O)[C@@H](NC(=O)\C(NC1=O)=C\NC(N)=O)[C@H]2CCNC(=N)N2

InChI

1S/C24H42N14O8.H2O4S/c25-4-1-2-10(26)17(40)32-7-13-19(42)34-14(8-33-24(29)46)20(43)38-16(12-3-5-30-23(28)37-12)22(45)31-6-11(27)18(41)36-15(9-39)21(44)35-13;1-5(2,3)4/h8,10-13,15-16,39H,1-7,9,25-27H2,(H,31,45)(H,32,40)(H,34,42)(H,35,44)(H,36,41)(H,38,43)(H3,28,30,37)(H3,29,33,46);(H2,1,2,3,4)/b14-8-;/t10-,11+,12?,13+,15-,16-;/m0./s1

InChI 密鑰

LFFNIXQXRKNZCE-UBBQZPMLSA-N

相关类别

應用

Capreomycin is used to study bacterial ribosomal subunit interactions and translocation processes during protein synthesis. It is a second line antibiotic and is used to study multidrug-resistant tuberculosis.

生化／生理作用

Capreomycin is a cyclic peptide antibiotic that is often grouped with aminoglycosides. It binds across the ribosomal interface involving 23S rRNA helix 69 (H69) and 16S rRNA helix 44 (h44).

準備報告

Sparingly soluble in water.

其他說明

Keep container tightly closed in a dry and well-ventilated place.

象形圖

Health hazardExclamation mark
GHS08,GHS07

訊號詞

Danger

危險分類

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Repr. 1B

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Rashid Akbergenov et al.
Antimicrobial agents and chemotherapy, 55(10), 4712-4717 (2011-07-20)
Capreomycin and the structurally similar compound viomycin are cyclic peptide antibiotics which are particularly active against Mycobacterium tuberculosis, including multidrug resistant strains. Both antibiotics bind across the ribosomal interface involving 23S rRNA helix 69 (H69) and 16S rRNA helix 44
B Reisfeld et al.
Antimicrobial agents and chemotherapy, 56(2), 926-934 (2011-12-07)
The emergence of multidrug-resistant tuberculosis (MDR-TB) has led to a renewed interest in the use of second-line antibiotic agents. Unfortunately, there are currently dearths of information, data, and computational models that can be used to help design rational regimens for
Courtney E Maus et al.
Antimicrobial agents and chemotherapy, 49(2), 571-577 (2005-01-28)
Capreomycin, an important drug for the treatment of multidrug-resistant tuberculosis, is a macrocyclic peptide antibiotic produced by Saccharothrix mutabolis subspecies capreolus. The basis of resistance to this drug was investigated by isolating and characterizing capreomycin-resistant strains of Mycobacterium smegmatis and
Chaiyos Roongruangpitayakul et al.
Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 96(10), 1273-1282 (2013-12-20)
Multi-drug-resistant/extensively drug-resistant tuberculosis (MDR/XDR-TB) becomes an increasing problem in management. Linezolid has been off-label used in treatment of MDR/XDR-TB with major adverse effects. To study outcomes of MDR/XDR-TB patients treated with linezolid in Central Chest Institute of Thailand. MDR/XDR-TB patients
DeDe Kwun-Wai Man et al.
mSphere, 3(4) (2018-07-20)
The mycobacterial cell wall affords natural resistance to antibiotics. Antimicrobial peptides (AMPs) modify the surface properties of mycobacteria and can act synergistically with antibiotics from differing classes. Here, we investigate the response of Mycobacterium smegmatis to the presence of rifampin
查看所有相关文献

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门