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Merck

39468

Sigma-Aldrich

α-氰基-4-羟基肉桂酸

matrix substance for MALDI-MS, Ultra pure

别名:

α-CCA, α-CHCA, α-氰基, 4-HCCA, ACCA

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About This Item

线性分子式:
HOC6H4CH=C(CN)CO2H
CAS号:
分子量:
189.17
Beilstein:
3271427
EC號碼:
MDL號碼:
分類程式碼代碼:
41116105
PubChem物質ID:
NACRES:
NA.21

等級

matrix substance for MALDI-MS

品質等級

形狀

solid

分析物化學類別

glycans, peptides, proteins

技術

MALDI-MS: suitable

mp

245-250 °C (lit.)
245-250 °C

溶解度

methanol: 10 mg/mL, clear

正離子痕跡

Al: ≤1 mg/kg
Ba: ≤1 mg/kg
Ca: ≤1 mg/kg
Cd: ≤1 mg/kg
Co: ≤1 mg/kg
Cr: ≤1 mg/kg
Cu: ≤1 mg/kg
Fe: ≤1 mg/kg
K: ≤1 mg/kg
Li: ≤1 mg/kg
Mg: ≤1 mg/kg
Mn: ≤1 mg/kg
Na: ≤1 mg/kg
Ni: ≤1 mg/kg
Pb: ≤1 mg/kg
Sr: ≤1 mg/kg
Zn: ≤1 mg/kg

儲存溫度

2-8°C

SMILES 字串

OC(=O)\C(=C\c1ccc(O)cc1)C#N

InChI

1S/C10H7NO3/c11-6-8(10(13)14)5-7-1-3-9(12)4-2-7/h1-5,12H,(H,13,14)/b8-5+

InChI 密鑰

AFVLVVWMAFSXCK-VMPITWQZSA-N

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一般說明

α-氰基-4-羟基肉桂酸(α-CHCA)起基质的作用,有助于在基质辅助激光解吸/电离(MALDI)飞行时间(TOF)质谱仪中促进蛋白质和肽的电离。

應用

它被用作基质,用于改善 MALDI-TOF 上低浓度蛋白质消化物的检测。

相關產品

产品编号
说明
价格

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Skin Sens. 1B

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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分析证书(COA)

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访问文档库

Xiangping Zhu et al.
Journal of biomolecular techniques : JBT, 14(4), 298-307 (2004-01-13)
Alpha-cyano-4-hydroxycinnamic acid (alpha-CHCA) as a matrix facilitates the ionization of proteins and peptides in a matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) mass spectrometer. The matrix itself also ionizes and so do its sodium and potassium adducts. Matrix clusters and metal
Zhiqiang Zhao et al.
Cancer letters, 342(1), 150-158 (2013-09-10)
Monocarboxylate transporter isoform 1 (MCT1) is an important member of the proton-linked MCT family and has been reported in an array of human cancer cell lines and primary human tumors. MCT1 expression is associated with developing a new therapeutic approach
Kamil Karolczak et al.
International journal of pharmaceutics, 436(1-2), 508-518 (2012-06-23)
We hypothesized that BBB is impaired in rat model of streptozotocin-induced diabetes and can be sealed by poly(amido)amine dendrimers G4.0 (PAMAM G4), which reveal anti-glycation activity. The BBB permeabilization was monitored in rats with the 60-day streptozotocin-diabetes and non-diabetic animals
Rossella Gottardo et al.
Journal of mass spectrometry : JMS, 47(1), 141-146 (2012-01-28)
Since 2004, a number of herbal blends containing different synthetic compounds mimicking the pharmacological activity of cannabinoids and displaying a high toxicological potential have appeared in the market. Their availability is mainly based on the so-called "e-commerce", being sold as
Mohammadreza Shariatgorji et al.
Analytical chemistry, 84(16), 7152-7157 (2012-08-07)
D(4)-α-Cyano-4-hydroxycinnamic acid (D(4)-CHCA) has been synthesized for use as a matrix for matrix-assisted laser desorption ionization-mass spectrometry (MALDI-MS) and MALDI-MS imaging (MSI) of small molecule drugs and endogenous compounds. MALDI-MS analysis of small molecules has historically been hindered by interference

商品

One of the most important aspects of our ultra-pure MALDI matrix substances is their ability to dissolve rapidly and completely; a brief vortex mixing is typically sufficient.

One of the most important aspects of our ultra-pure MALDI matrix substances is their ability to dissolve rapidly and completely; a brief vortex mixing is typically sufficient.

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