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Merck
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36687

Supelco

4-氨基吡啶

PESTANAL®, analytical standard

别名:

4-吡啶胺, 4AP, 对氨基吡啶, 氨吡啶

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About This Item

经验公式（希尔记法）:
C5H6N2
CAS号:
504-24-5
分子量:
94.11
Beilstein:
105782
EC號碼:
207-987-9
MDL號碼:
MFCD00006439
分類程式碼代碼:
41116107
PubChem物質ID:
329755452
NACRES:
NA.24

等級

analytical standard

品質等級

100

產品線

PESTANAL®

儲存期限

limited shelf life, expiry date on the label

技術

HPLC: suitable
gas chromatography (GC): suitable

bp

273 °C (lit.)

mp

155-158 °C (lit.)

應用

agriculture
environmental

格式

neat

SMILES 字串

Nc1ccncc1

InChI

1S/C5H6N2/c6-5-1-3-7-4-2-5/h1-4H,(H2,6,7)

InChI 密鑰

NUKYPUAOHBNCPY-UHFFFAOYSA-N

基因資訊

human ... KCNA1(3736) , KCNA10(3744) , KCNA2(3737) , KCNA3(3738) , KCNA4(3739) , KCNA5(3741) , KCNA6(3742) , KCNA7(3743) , KCNB1(3745) , KCNB2(9312) , KCNC1(3746) , KCNC2(3747) , KCNC3(3748) , KCNC4(3749) , KCND1(3750) , KCND2(3751) , KCND3(3752) , KCNF1(3754) , KCNG1(3755) , KCNG2(26251) , KCNG3(170850) , KCNG4(93107) , KCNH1(3756) , KCNH2(3757) , KCNH3(23416) , KCNH4(23415) , KCNH5(27133) , KCNH6(81033) , KCNH7(90134) , KCNH8(131096) , KCNQ1(3784) , KCNQ2(3785) , KCNQ3(3786) , KCNQ4(9132) , KCNQ5(56479) , KCNS1(3787) , KCNS2(3788) , KCNS3(3790) , KCNV1(27012) , KCNV2(169522)

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一般說明

4-Aminopyridine is a small molecule potassium channel blocker, which stimulates the release of glutamate from nerve terminals and induces seizures. It can also be used as a drug that aims to improve ambulatory impairment, a major symptom of multiple sclerosis disease.

應用

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

法律資訊

PESTANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

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訊號詞

Danger

危險分類

Acute Tox. 2 Oral - Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Aquatic Chronic 2 - Eye Dam. 1 - Skin Corr. 1B

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類（WGK）

WGK 3

閃點（°F）

312.8 °F

閃點（°C）

156 °C

個人防護裝備

dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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分析证书(COA)

Lot/Batch Number
BCCG8622
BCCD4391
BCCB6978
BCBZ4641
BCBT9646

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Berberine attenuates convulsing behavior and extracellular glutamate and aspartate changes in 4-aminopyridine treated rats
Sadeghnia RH, et al.
Iranian Journal of Basic Medical Sciences, 20, 588-588 (2017)
4-Aminopyridine ameliorates experimental autoimmune neuritis in Lewis rats
Moriguchi K, et al.
Journal of Neuroimmunology, 305, 72-74 (2017)
Michael T Roberts et al.
Neuron, 78(5), 923-935 (2013-06-15)
Feedforward inhibition sharpens the precision of neurons throughout ascending auditory pathways, including the binaural neurons of the medial superior olive (MSO). However, the biophysical influence of inhibition is poorly understood, particularly at higher frequencies at which the relative phase of
Jens Claassen et al.
Journal of neurology, neurosurgery, and psychiatry, 84(12), 1392-1399 (2013-07-03)
The effects of 4-aminopyridine (4-AP) on downbeat nystagmus (DBN) were analysed in terms of slow-phase velocity (SPV), stance, locomotion, visual acuity (VA), patient satisfaction and side effects using standardised questionnaires. Twenty-seven patients with DBN received 5 mg 4-AP four times
R I Westphalen et al.
British journal of anaesthesia, 110(4), 592-599 (2012-12-06)
Presynaptic effects of general anaesthetics are not well characterized. We tested the hypothesis that isoflurane exhibits transmitter-specific effects on neurotransmitter release from neurochemically and functionally distinct isolated mammalian nerve terminals. Nerve terminals from adult male rat brain were prelabelled with
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