MABC522

Anti-MAP17 Antibody, clone 165C

clone 165C, from mouse

• 别名: PDZK1-interacting protein 1, 17 kDa membrane-associated protein, Protein DD96
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

属性

• 生物源: mouse
• 品質等級: 100
• 抗體表格: purified antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: 165C, monoclonal
• 物種活性: human
• 技術: immunohistochemistry: suitable; western blot: suitable
• 同型: IgG1κ
• NCBI登錄號: NP_005755
• UniProt登錄號: Q13113
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... PDZK1IP1(10158)

说明

一般說明

The protein named PDZK1-interacting protein 1 or alternatively 17kDa membrane-associated protein DD96 or MAP17 and encoded by the human gene named PDZK1IP1 or MAP17 is a highly unusual protein being naturally expressed only in a single epithelial cell population found in the proximal tubular epithelial cells. However, MAP17 is expressed in cancerous tissue of the kidney, colon, lung and breast. MAP17 expression in cancers causes an increase in reactive oxygen species production and tumorigenesis in cancerous tissues. These factors are mediated though MAP17’s PDZ-binding domain because disruption of this sequence by point mutations abolishes the ability of MAP17 to enhance ROS production and tumorigenesis. MAP17 also often serves as a cancer cell marker to distinguish tumor margins and tumorigenesis potential. MAP17 is a membrane bound protein and is thought to be a putative oncogene but its exact function in normal cells is still being researched.

免疫原

GST-tagged recombinant protein corresponding to human MAP17.

應用

Anti-MAP17 Antibody, clone 165C is a highly specific mouse monoclonal antibody, that targets MAP17 & has been tested in western blotting & IHC.

Research Category
Apoptosis & Cancer

Research Sub Category
Apoptosis - Additional

Western Blotting Analysis: 1.0 µg/mL from a representative lot detected MAP17 in 10 µg of human salivary gland tissue lysate.
Immunohistochemistry Analysis: A 1:500-2,000 dilution from a representative lot detected MAP17 in human prostate cancer and human kidney tissue.

品質

Evaluated by Western Blotting in human kidney tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected MAP17 in 10 µg of human kidney tissue lysate.

標靶描述

~20 kDa observed

外觀

Protein G Purified

Format: Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

其他說明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全信息

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable