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Key Documents

MAB2052

Sigma-Aldrich

抗-双唾液酸神经节苷脂GD2抗体,克隆14G2a

clone 14.2Ga, Chemicon®, from mouse

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About This Item

分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物源

mouse

品質等級

抗體表格

affinity purified immunoglobulin

抗體產品種類

primary antibodies

無性繁殖

14.2Ga, monoclonal

物種活性

human

製造商/商標名

Chemicon®

技術

flow cytometry: suitable
immunofluorescence: suitable
immunohistochemistry: suitable

同型

IgG2a

運輸包裝

wet ice

目標翻譯後修改

unmodified

特異性

与人 GD2 神经节苷脂特异性反应。

應用

免疫组织化学(冷冻组织切片)(Cheresh et al.,1986)

培养细胞的免疫荧光

流式细胞术:每10E6个细胞1-2 μg

对GD2阳性细胞的细胞毒性(Mujoo et al., 1987, 1989)

最佳工作稀释度必须由最终用户确定。
抗双唾液酸神经节苷脂抗体,clone 14G2a 检测双唾液酸神经节苷脂 GD2 &的水平,已发表验证可用于 FC、IF、IH。

外觀

形式:纯化
溶于0.02 M PB pH值7.6、0.25 M NaCl、含有0.1%叠氮化钠的细胞培养上清液。

其他說明

浓度:请参考批次特异性浓缩物的检验报告。

法律資訊

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Functional properties and effect on growth suppression of human neuroblastoma tumors by isotype switch variants of monoclonal antiganglioside GD2 antibody 14.18.
Mujoo, K, et al.
Cancer Research, 49, 2857-2861 (1989)
Biosynthesis and expression of the disialoganglioside GD2, a relevant target antigen on small cell lung carcinoma for monoclonal antibody-mediated cytolysis.
Cheresh, D A, et al.
Cancer Research, 46, 5112-5118 (1986)
Patrizia Garbati et al.
Biomedicines, 8(11) (2020-11-07)
To overcome the lack of effective pharmacological treatments for high-risk neuroblastoma (HR-NB), the development of novel in vitro and in vivo models that better recapitulate the disease is required. Here, we used an in vitro multiclonal cell model encompassing NB
Hideki Yoshida et al.
Scientific reports, 10(1), 1199-1199 (2020-01-29)
β-1,4-N-Acetyl-Galactosaminyltransferase 1 (B4GALNT1) encodes the key enzyme B4GALNT1 to generate gangliosides GM2/GD2. GM2/GD2 gangliosides are surface glycolipids mainly found on brain neurons as well as peripheral nerves and skin melanocytes and are reported to exacerbate the malignant potential of melanomas.
Isolation of retinal progenitor cells from post-mortem human tissue and comparison with autologous brain progenitors.
Henry Klassen, Boback Ziaeian, Ivan I Kirov, Michael J Young, Philip H Schwartz
Journal of Neuroscience Research null

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