ABE69
Anti-PTIP Antibody
from chicken, purified by affinity chromatography
别名:
PAX interacting (with transcription-activation domain) protein 1, PAX transactivation activation domain-interacting protein, protein encoded by CAG trinucleotide repeats, PAX transcription activation domain interacting protein 1 like
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所有图片(1)
About This Item
分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41
推荐产品
生物源
chicken
品質等級
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
純化經由
affinity chromatography
物種活性
rat, mouse, human
技術
immunofluorescence: suitable
immunohistochemistry: suitable
western blot: suitable
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
目標翻譯後修改
unmodified
基因資訊
human ... PAXIP1(22976)
一般說明
PAX transactivation activation domain-interacting protein (PTIP) is a ubiquitous nuclear protein composed of 5 tandem BRCA1 carboxyl-terminal (BRCT) domains. PTIP was initially identified as an interacting, transactivation protein that binds to the C-terminal end of Pax2. Since its discovery, studies have shown PTIP to bind several Pax proteins, playing a critical role in response to DNA damage. It also has activity as a phosphoserine/ phosphothreonine-specific binding module, and can discern ATM and ATR gamma irradiation induced phosphorylated substrates. PTIP is involved in early cellular development and is likely to have a role in cell proliferation as well.
免疫原
Histidine-tagged recombinant protein corresponding to human PTIP.
應用
Anti-PTIP Antibody is a Chicken Polyclonal Antibody for detection of PTIP also known as PAX transactivation activation domain-interacting protein, protein encoded by CAG trinucleotide repeats & has been validated in WB, IHC & IF.
Immunohistochemistry Analysis: A representative lot was used by an independent laboratory in IH (Patel, S., et al. (2007).
Immunofluorescence Analysis: A represenative lot was used by an independent laboratory in IF (Lechner, M., et al. (2000).
Immunofluorescence Analysis: A represenative lot was used by an independent laboratory in IF (Lechner, M., et al. (2000).
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Chromatin Biology
Chromatin Biology
品質
Evaluated by Western Blot in A431 cell lysate.
Western Blot Analysis: A 1:1,000 dilution of this antibody detected PTIP in 10 µg of A431 cell lysate.
Western Blot Analysis: A 1:1,000 dilution of this antibody detected PTIP in 10 µg of A431 cell lysate.
標靶描述
~120 kDa observed.
Other isoforms may be observed in some lysates.
Other isoforms may be observed in some lysates.
外觀
Affinity purified
Purified chicken polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
儲存和穩定性
Stable for 1 year at 2-8°C from date of receipt.
分析報告
Control
A431 cell lysate
A431 cell lysate
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Rachel Bayley et al.
Molecular cell, 82(10), 1924-1939 (2022-04-20)
The 53BP1-RIF1-shieldin pathway maintains genome stability by suppressing nucleolytic degradation of DNA ends at double-strand breaks (DSBs). Although RIF1 interacts with damaged chromatin via phospho-53BP1 and facilitates recruitment of the shieldin complex to DSBs, it is unclear whether other regulatory
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