I8898

伊维菌素

• 别名: 22,23-二氢阿维菌素 B1, MK-933
• CAS号: 70288-86-7
• MDL號碼: MFCD00869511
• 分類程式碼代碼: 12352200
• PubChem物質ID: 24278497
• NACRES: NA.77

属性

• 形狀: powder
• 品質等級: 100
• 溶解度: MEK: 50 mg/mL
• 抗生素活性譜: parasites
• 應用: agriculture; environmental
• 作用方式: cell membrane | interferes
• 起源: Merck & Co., Inc., Kenilworth, NJ, U.S.
• 儲存溫度: 2-8°C
• SMILES 字串: [H][C@@]1(O[C@]2(CC[C@@H]1C)C[C@@H]3C[C@@H](C\C=C(C)\[C@@H](O[C@H]4C[C@H](OC)[C@@H](O[C@H]5C[C@H](OC)[C@@H](O)[C@H](C)O5)[C@H](C)O4)[C@@H](C)\C=C\C=C6/CO[C@]7([H])[C@H](O)C(C)=C[C@@H](C(=O)O3)[C@]67O)O2)[C@@H](C)CC
• InChI: 1S/C48H74O14/c1-11-25(2)43-28(5)17-18-47(62-43)23-34-20-33(61-47)16-15-27(4)42(26(3)13-12-14-32-24-55-45-40(49)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-10)44(31(8)57-39)60-38-21-36(53-9)41(50)30(7)56-38/h12-15,19,25-26,28,30-31,33-45,49-50,52H,11,16-18,20-24H2,1-10H3/b13-12+,27-15+,32-14+/t25-,26-,28-,30-,31-,33+,34-,35-,36-,37-,38-,39-,40+,41-,42-,43+,44-,45+,47+,48+/m0/s1
• InChI 密鑰: AZSNMRSAGSSBNP-XPNPUAGNSA-N
• 基因資訊: human ... ABCB1(5243) , CYP3A4(1576) ; mouse ... Abcb1a(18671) , Abcb1b(18669)

说明

一般說明

Ivermectin is a macro-cyclic lactone, derived from avermectin. It functions as an antiparasitic agent. Ivermectin is used against gastrointestinal roundworms, lungworms, mites and lice. It is used to treat onchocerciasis, strongyloidiasis, ascariasis and filariases.

應用

Ivermectin has been used:

• in Caenorhabditis elegans fecundity assay
• in larval development test
• to measure in vivo topical acaricide activity of compounds in rats
• to assess its acute and chronic effects to zebrafish
• in percutaneous drug injection method to treat cystic echinococcosis
• in liquid chromatography with fluorescence detection method

生化／生理作用

Positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptor; also modulates glutamate-GABA-activated chloride channels.

特點和優勢

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

其他說明

Primarily ivermectin B_1a.

安全信息

• 象形圖: GHS06,GHS08,GHS09
• 訊號詞: Danger
• 危險聲明: H300,H311,H351,H360D,H410
• 防範說明: P202 - P264 - P273 - P280 - P301 + P310 - P302 + P352 + P312
• 危險分類: Acute Tox. 1 Oral - Acute Tox. 3 Dermal - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Repr. 1B
• 儲存類別代碼: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges