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品質等級
化驗
≥98% (HPLC)
形狀
liquid
製造商/商標名
Calbiochem®
儲存條件
OK to freeze
desiccated (hygroscopic)
protect from light
運輸包裝
wet ice
儲存溫度
2-8°C
InChI
1S/C18H16FN3O/c1-18(2,3)17-21-14-10-5-4-9(19)8-12(10)13-11(15(14)22-17)6-7-20-16(13)23/h4-8H,1-3H3,(H,20,23)(H,21,22)
InChI 密鑰
VNDWQCSOSCCWIP-UHFFFAOYSA-N
一般說明
Janus蛋白酪氨酸激酶(JAKs)的有效抑制剂。显示对JAK1(对于鼠JAK1,IC50=15 nM)、JAK2(IC50=1 nM)、JAK3(Ki=5 nM)和Tyk2(IC50=1 nM)的有效抑制活性。它仅在高得多的浓度下抑制其他激酶。还抑制CTLL细胞的IL-2和IL-4依赖性增殖,并阻断STAT5的磷酸化。
生化/生理作用
5 nM,针对JAK3
主要靶标
鼠JAK1
鼠JAK1
产物与ATP竞争。
可逆性:是
细胞可渗透性:是
靶标IC50:分别针对鼠JAK1和JAK2的15 nM,1 nM;针对Tyk2为1 nM
包裝
用惰性气体包装
警告
毒性:刺激性(B)
外觀
10 mM(500 µg/162 µl)JAK抑制剂I(目录号420099)的DMSO溶液。
重構
初次使用后,等分并冷藏(4°C)。
其他說明
Thompson, J.E., et al. 2002.Bioorg.Med. Chem. Lett.12, 1219.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
10 - Combustible liquids
水污染物質分類(WGK)
WGK 2
閃點(°F)
188.6 °F - closed cup - (Dimethylsulfoxide)
閃點(°C)
87 °C - closed cup - (Dimethylsulfoxide)
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