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生物源
synthetic (organic)
品質等級
化驗
≥98% (HPLC)
形狀
solid
顏色
yellow
溶解度
DMSO: soluble 10 mg/ml, clear, yellow
ethanol: 5 mg/mL
H2O: insoluble
儲存溫度
−20°C
SMILES 字串
Oc1ccc(cc1O)\C=C(/C#N)C(=O)NCc2ccccc2
InChI
1S/C17H14N2O3/c18-10-14(8-13-6-7-15(20)16(21)9-13)17(22)19-11-12-4-2-1-3-5-12/h1-9,20-21H,11H2,(H,19,22)/b14-8+
InChI 密鑰
TUCIOBMMDDOEMM-RIYZIHGNSA-N
基因資訊
human ... EGFR(1956) , ERBB2(2064) , IL2(3558) , JAK2(3717)
應用
Tyrphostin AG 已被用于阻断 IL-6 细胞因子信号传导,研究其对神经胶质细胞反应性的影响 5 。AG 490 也被用作人脐静脉内皮细胞的 JAK2 抑制剂 6 。
生化/生理作用
Jak-2 蛋白酪氨酸激酶 (PTK) 抑制剂。抑制白细胞介素 2 (IL-2) 驱动的有丝分裂并触发 Sezary 综合征(一种皮肤 T 细胞淋巴瘤的白血病变体)的肿瘤细胞凋亡。
特點和優勢
该化合物是激酶磷酸酶生物学研究的特色产品。 点击此处 ,发现更多特色激酶磷酸酶生物学产品。在 sigma.com/discover-bsm了解更多关于其他研究领域的生物活性小分子。
注意
光敏
準備報告
Tyrphostin AG 490 溶于乙醇,浓度为 5 mg/mL,不溶于水。也可溶于 10 mg/mL 的 DMSO 中,并产生澄清的黄色溶液。
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
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