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W6578

Sigma-Aldrich

丙酮酸-1-13C（游离酸）

API for Clinical Studies, ≥99 atom % 13C

别名:

α-酮丙酸-1-13C, 2-氧丙酸-1-13C, 13C 标记丙酮酸, 丙酮酸-1-13C

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About This Item

线性分子式:
CH3CO13CO2H
CAS号:
99124-30-8
分子量:
89.05
MDL號碼:
MFCD10566986
分類程式碼代碼:
12352106
PubChem物質ID:
329830758
NACRES:
NA.12

等級

cGMP

品質等級

400

同位素純度

≥99 atom % 13C

化驗

≥95% (CP)

bp

165 °C

mp

11-12 °C

質量偏移

M+1

運輸包裝

dry ice

儲存溫度

-10 to -25°C

SMILES 字串

CC(=O)[13C](O)=O

InChI

1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/i3+1

InChI 密鑰

LCTONWCANYUPML-LBPDFUHNSA-N

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相关类别

一般說明

Pyruvic-1-13C is isotopic labeled precursor of pyruvic acid.

應用

Hyperpolarized 13C-labeled pyruvate and its metabolite lactate has been used to image real time metabolic flux in solid tumors and assess tumor response to chemotherapy, radiation, and agents targeting mTOR.

包裝

Typically, this product is available to ship immediately from stock. Contact Stable Isotopes Customer Service to discuss quantity and packaging needs.

象形圖

Corrosion
GHS05

訊號詞

Danger

危險聲明

H314

危險分類

Eye Dam. 1 - Skin Corr. 1C

儲存類別代碼

8A - Combustible corrosive hazardous materials

水污染物質分類（WGK）

WGK 1

閃點（°F）

179.6 °F - closed cup

閃點（°C）

82 °C - closed cup

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分析证书(COA)

Lot/Batch Number
MBBD2752
MBBC8639
MBBC6060
MBBC7230
MBBC1551

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丙酮酸钠-13C3 99 atom % 13C

Sigma-Aldrich

490717

丙酮酸钠-13C3

丙酮酸 98%

Sigma-Aldrich

107360

丙酮酸

Ilwoo Park et al.
Journal of magnetic resonance imaging : JMRI, 33(6), 1284-1290 (2011-05-19)
To demonstrate the feasibility of using DNP hyperpolarized [1-(13)C]-pyruvate to measure early response to temozolomide (TMZ) therapy using an orthotopic human glioblastoma xenograft model. Twenty athymic rats with intracranial implantation of human glioblastoma cells were divided into two groups: one
Mette Hauge Lauritzen et al.
NMR in biomedicine, 26(11), 1496-1500 (2013-06-25)
A change in myocardial metabolism is a known effect of several diseases. MRS with hyperpolarized (13)C-labelled pyruvate is a technique capable of detecting changes in myocardial pyruvate metabolism, and has proven to be useful for the evaluation of myocardial ischaemia
Prasanta Dutta et al.
Cancer research, 73(14), 4190-4195 (2013-06-01)
Hyperpolarized (13)C magnetic resonance spectroscopy provides a unique opportunity to detect real-time metabolic fluxes as a means to measure metabolic treatment responses in vivo. Here, we show that pharmacologic inhibition of lactate dehydrogenase-A suppressed the conversion of hyperpolarized (13)C-pyruvate to
Albert P Chen et al.
Magnetic resonance in medicine, 73(6), 2087-2093 (2014-07-22)
Hyperpolarized [1-(13) C]lactate in solution may be a clinically relevant and safe substrate for real time MR investigations of key metabolic pathways. The potential of using hyperpolarized [1-(13) C]lactate for magnetic resonance studies of cardiac metabolism in vivo was explored.

商品

MRI/MRS: Use of Isotopes in Hyperpolarization

Sigma-Aldrich.com presents an article concerning MRI/MRS and the use of isotopes in hyperpolarization.

MRI/MRS: Use of Isotopes in Hyperpolarization

Sigma-Aldrich.com presents an article concerning MRI/MRS and the use of isotopes in hyperpolarization.

Dynamic Nuclear Polarization

Dynamic Nuclear Polarization (DNP) is a phenomenon by which high spin polarization, typically derived from a bath of free radical electrons, is transferred to a nuclear spin bath, enhancing the difference between the nuclear energy levels and thereby producing dramatically enhanced NMR signals for detection.

Dynamic Nuclear Polarization

Dynamic Nuclear Polarization (DNP) is a phenomenon by which high spin polarization, typically derived from a bath of free radical electrons, is transferred to a nuclear spin bath, enhancing the difference between the nuclear energy levels and thereby producing dramatically enhanced NMR signals for detection.

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