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677175

Sigma-Aldrich

丙酮酸-1-13C（游离酸）

≥99 atom % 13C, ≥99% (CP)

别名:

α-酮丙酸-1-13C, 2-氧丙酸-1-13C, 13C 标记丙酮酸, 丙酮酸-1-13C

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About This Item

线性分子式:
CH3CO13CO2H
CAS号:
99124-30-8
分子量:
89.05
MDL號碼:
MFCD10566986
分類程式碼代碼:
12352106
PubChem物質ID:
329760673
NACRES:
NA.12

同位素純度

≥99 atom % 13C

化驗

≥99% (CP)

bp

165 °C

mp

11-12 °C

密度

1.281 g/mL at 25 °C

質量偏移

M+1

運輸包裝

dry ice

儲存溫度

−20°C

SMILES 字串

CC(=O)[13C](O)=O

InChI

1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/i3+1

InChI 密鑰

LCTONWCANYUPML-LBPDFUHNSA-N

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相关类别

一般說明

Pyruvic-1-13C 是同位素标记的丙酮酸前体。

應用

超极化 13C标记的丙酮酸及其代谢产物乳酸，用于对实体肿瘤实时代谢通量进行成像，评估肿瘤对化疗、放疗和靶向mTOR药物的反应情况。

包裝

该产品可以大包装形式供货，也可按需进行包装。 如需关于价格、供货形式及包装的信息，请联系稳定同位素客户服务。

象形圖

Corrosion
GHS05

訊號詞

Danger

危險聲明

H314

危險分類

Eye Dam. 1 - Skin Corr. 1C

儲存類別代碼

8A - Combustible corrosive hazardous materials

水污染物質分類（WGK）

WGK 1

閃點（°F）

179.6 °F - closed cup

閃點（°C）

82 °C - closed cup

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Ilwoo Park et al.
Journal of magnetic resonance imaging : JMRI, 33(6), 1284-1290 (2011-05-19)
To demonstrate the feasibility of using DNP hyperpolarized [1-(13)C]-pyruvate to measure early response to temozolomide (TMZ) therapy using an orthotopic human glioblastoma xenograft model. Twenty athymic rats with intracranial implantation of human glioblastoma cells were divided into two groups: one
Mette Hauge Lauritzen et al.
NMR in biomedicine, 26(11), 1496-1500 (2013-06-25)
A change in myocardial metabolism is a known effect of several diseases. MRS with hyperpolarized (13)C-labelled pyruvate is a technique capable of detecting changes in myocardial pyruvate metabolism, and has proven to be useful for the evaluation of myocardial ischaemia
Prasanta Dutta et al.
Cancer research, 73(14), 4190-4195 (2013-06-01)
Hyperpolarized (13)C magnetic resonance spectroscopy provides a unique opportunity to detect real-time metabolic fluxes as a means to measure metabolic treatment responses in vivo. Here, we show that pharmacologic inhibition of lactate dehydrogenase-A suppressed the conversion of hyperpolarized (13)C-pyruvate to
Albert P Chen et al.
Magnetic resonance in medicine, 73(6), 2087-2093 (2014-07-22)
Hyperpolarized [1-(13) C]lactate in solution may be a clinically relevant and safe substrate for real time MR investigations of key metabolic pathways. The potential of using hyperpolarized [1-(13) C]lactate for magnetic resonance studies of cardiac metabolism in vivo was explored.

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