ALD00613

PSI²

• 别名: Ψ², 2-(Perfluorophenoxy)-1,3,2-dithiaphospholane 2-sulfide, Achiral phosphorus-sulfur Incorporation reagent
• 经验公式（希尔记法）: C₈H₄F₅OPS₃
• 分子量: 338.28
• 分類程式碼代碼: 12352005
• NACRES: NA.22

属性

• 形狀: powder
• 品質等級: 100
• mp: 94-97 °C

说明

應用

PSI² is a stable and sustainably prepared P(V) reagent developed by the Baran Lab for the synthesis of phosphorodithioate oligonucleotides. The phosphorodithioate linkages afforded by PSI² are effectively cleaved by RNAse-H while remaining stable to nucleases, and can be formed rapidly in high yield. The synthetic methodology accessed by PSI² and other PSI reagents (see ALD00602 and ALD00604) allows at will installation of a greater diversity of linkages to DNA and other nucleotides with comparable performance to existing state-of-the-art P(III) based reagents. The resulting compounds have applications in gene-based therapeutics such as antisense oligonucleotides (ASOs).

Learn more about PI and PSI reagents

其他說明

Unlocking P(V): Reagents for chiral phosphorothioate synthesis

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable