930237

2,5-dioxopyrrolidin-1-yl (2,5-dichlorobenzoyl)glycyl-L-leucinate

≥95%

• 别名: CANDDY_MLN Tag NHS ester
• 经验公式（希尔记法）: C₁₉H₂₁Cl₂N₃O₆
• 分子量: 458.29
• 分類程式碼代碼: 12352209
• NACRES: NA.21

属性

• 品質等級: 100
• 化驗: ≥95%
• 形狀: powder
• 儲存溫度: 2-8°C
• SMILES 字串: ClC1=CC=C(Cl)C(C(NCC(N[C@H](C(ON2C(CCC2=O)=O)=O)CC(C)C)=O)=O)=C1

说明

應用

CANDDY (Chemical knockdown with Affinity aNd Degradation DYnamics) employs a bispecific molecule (target interactor + linker + CANDDY_MLN) that degrades protein by direct recruitment to the proteasome. Shown to selectively and dose-dependently degrade KRAS G12D/V and MDM2 proteins and suppress their signaling without non-specific cytotoxic effects.

CANDDY, a protein-slaying approach, occurs without ubiquitination and bypasses the need for an E3 ligase. Has the potential to overcome the current limitations of proteolysis and to expand the application scope of degraders.

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable