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130672

Sigma-Aldrich

N-羟基丁二酰亚胺

98%

别名:

1-羟基-2,5-吡咯烷二酮, HOSu, NHS

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About This Item

经验公式（希尔记法）:
C4H5NO3
CAS号:
6066-82-6
分子量:
115.09
Beilstein:
113913
EC號碼:
228-001-3
MDL號碼:
MFCD00005516
分類程式碼代碼:
12352115
PubChem物質ID:
24847975
NACRES:
NA.22

化驗

98%

形狀

solid

mp

95-98 °C (lit.)

官能基

imide

SMILES 字串

ON1C(=O)CCC1=O

InChI

1S/C4H5NO3/c6-3-1-2-4(7)5(3)8/h8H,1-2H2

InChI 密鑰

NQTADLQHYWFPDB-UHFFFAOYSA-N

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應用

N-羟基琥珀酰亚胺可以在存在二环己基碳二亚胺的条件下在羧酸中通过脱水反应合成N-羟基琥珀酰亚胺酯。
N-羟基琥珀酰亚胺已用于中间介质的合成如：
  • N

  • -丁二酰亚胺3-(二-三-丁基氟硅烷）苯甲酸
  • 4-[2,2-双[(对-甲苯磺酰)-甲基]乙酰]苯甲酸-NHS酯
  • N-丁二酰亚胺3-碘苯甲酸

它还用于微流体整合的表面等离子体共振（SPR）平台的微通道的表面修饰的实验方法中，用于对细菌病原体进行检测和定量。
碳二亚胺方法中使用的添加剂用于改良的酰胺化及肽偶联。

象形圖

Corrosion
GHS05

訊號詞

Danger

危險聲明

H315,H318

危險分類

Eye Dam. 1 - Skin Irrit. 2

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCQ9380
WXBD6833V
WXBD4823V
MKCQ0582
WXBD5631V

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Pico Y et al.
Food Toxicants Analysis: Techniques, Strategies and Developments (2007)
Cong Li et al.
Journal of the American Chemical Society, 128(47), 15072-15073 (2006-11-23)
The conjugate of bacterial cytosine deaminase (bCD) and poly-l-lysine (PLL) that was functionalized with biotin, rhodamine, and Gd3+-DOTA was synthesized and characterized. It demonstrated high relaxivity, improved enzymatic specificity to prodrug 5-fluorocytosine, low cytotoxicity, efficient cell uptake, and high enzymatic
D Sehgal et al.
Analytical biochemistry, 218(1), 87-91 (1994-04-01)
Water-soluble carbodiimides are widely used for carboxyl-amine conjugation. However, extremely variable and low yields, obtained under a variety of conditions, have been a serious problem in the coupling. A simple method, optimizing various parameters of the coupling reaction, in which
Zbigniew Czajgucki et al.
Journal of peptide science : an official publication of the European Peptide Society, 12(10), 653-662 (2006-07-19)
Edeines are pentapeptide amide antibiotics composed of four nonprotein amino acids, glycine, and polyamine. They exhibit antimicrobial and immunosuppressive activities and are universal inhibitors of translation. Moreover, it was proven that the free ionizable carboxy group in the (2R, 6S
PEGylation of native disulfide bonds in proteins.
Brocchini S
Nature Protocols, 1(5), 2241-2241 (2006)
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