Skip to Content
MilliporeSigma
All Photos(1)

Key Documents

View All Documentation

1250008

USP

Estradiol

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

β-Estradiol, 1,3,5-Estratriene-3,17β-diol, 17β-Estradiol, 3,17β-Dihydroxy-1,3,5(10)-estratriene, Dihydrofolliculin

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C18H24O2
CAS Number:
50-28-2
Molecular Weight:
272.38
Beilstein/REAXYS Number:
1914275
MDL number:
MFCD00003693
UNSPSC Code:
41116107
PubChem Substance ID:
329749749
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

estradiol

manufacturer/tradename

USP

mp

176-180 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

O[C@H]1CC[C@@]2([H])[C@]3([H])CCC4=CC(O)=CC=C4[C@@]3([H])CC[C@@]21C

InChI

1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1

InChI key

VOXZDWNPVJITMN-ZBRFXRBCSA-N

Gene Information

human ... ESR1(2099)

Looking for similar products? Visit Product Comparison Guide

Related Categories

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Biochem/physiol Actions

The major estrogen secreted by the premenopausal ovary.
The major estrogen secreted by the premenopausal ovary. Estrogens direct the development of the female phenotype in embryogenesis and during puberty by regulating gene transcription and, thus, protein synthesis. It also induces the production of gonadotropins which, in turn, induce ovulation. Exposure to estradiol increases breast cancer incidence and proliferation.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Related product

Product No.
Description
Pricing

Y0000314

Estradiol for peak identification, European Pharmacopoeia (EP) Reference Standard

E1620000

Estradiol hemihydrate, European Pharmacopoeia (EP) Reference Standard

E1600000

Estradiol benzoate, European Pharmacopoeia (EP) Reference Standard

Y0000046

Estradiol valerate, European Pharmacopoeia (EP) Reference Standard

Y0000852

Estradiol benzoate for system suitability, European Pharmacopoeia (EP) Reference Standard

1252003

Estradiol cypionate, United States Pharmacopeia (USP) Reference Standard

1251000

Estradiol benzoate, United States Pharmacopeia (USP) Reference Standard

BP729

Estradiol hemihydrate, British Pharmacopoeia (BP) Assay Standard

1254009

Estradiol valerate, United States Pharmacopeia (USP) Reference Standard

1250041

Estradiol Related Compound C, United States Pharmacopeia (USP) Reference Standard

1250020

Estradiol Related Compound B, United States Pharmacopeia (USP) Reference Standard

1252193

Estradiol cypionate System Suitability Mixture, United States Pharmacopeia (USP) Reference Standard

Y0001823

Estradiol valerate for system suitability, European Pharmacopoeia (EP) Reference Standard

BP396

Estradiol benzoate, British Pharmacopoeia (BP) Reference Standard

1254031

Estradiol Valerate Identification Mixture, United States Pharmacopeia (USP) Reference Standard

PHR2228

Estradiol 3-Methyl Ether, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2227

Estradiol Impurity L, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2839

Estradiol Cypionate, certified reference material, pharmaceutical secondary standard

PHR2857

Estradiol Valerate, certified reference material, pharmaceutical secondary standard

PHR2858

Estradiol Benzoate, certified reference material, pharmaceutical secondary standard

PHR2859

Estradiol Related Compound C, pharmaceutical secondary standard, certified reference material

pictograms

Health hazardEnvironment
GHS08,GHS09

signalword

Danger

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Lact. - Repr. 1A

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Estradiol and Norethindrone Acetate Tablets
United States Pharmacopeia, 44(6) (2023)
L-P Boulet
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 45(1), 75-86 (2014-10-18)
The prevalence of obesity has increased worldwide, and weight gain has been shown to influence the development and clinical expression of various conditions including asthma. The relationships between atopy and obesity remain uncertain, both in adults and in children. Although
Marie Mi Bonde et al.
Nucleic acids research, 42(20), 12847-12860 (2014-10-30)
Splicing reactions generally combine high speed with accuracy. However, some of the pre-mRNAs escape the nucleus with a retained intron. Intron retention can control gene expression and increase proteome diversity. We calculated the escape rate for the yeast PTC7 intron
Amit Cohen et al.
Zebrafish, 11(5), 462-478 (2013-06-19)
Estrogen is a steroid hormone that has been implicated in a variety of cellular and physiological processes and in the development of diseases such as cancer. Here we show a remarkable widespread microRNA (miRNA) downregulation in the zebrafish (Danio rerio)
Rucha S Sane et al.
The Journal of pharmacology and experimental therapeutics, 351(2), 403-412 (2014-09-11)
Faldaprevir, an investigational agent for hepatitis C virus treatment, is well tolerated but associated with rapidly reversible, dose-dependent, clinically benign, unconjugated hyperbilirubinemia. Multidisciplinary preclinical and clinical studies were used to characterize mechanisms underlying this hyperbilirubinemia. In vitro, faldaprevir inhibited key
View All Related Papers

Articles

UHPLC Analysis of Conjugated Estrogens on Ascentis ® Express C18

Separation of Estriol 3-(β-D-glucuronide) sodium salt; β-Estradiol 3-(β-D-glucuronide) 17-sulfate dipotassium salt; Estriol 3-sulfate sodium salt; β-Estradiol 3,17-disulfate dipotassium salt, ≥95%; β-Estradiol 17-(β-D-glucuronide) sodium salt; β-Estradiol 3-(β-D-glucuronide) sodium salt; Estrone 3-(β-D-glucuronide) sodium salt; β-Estradiol 3-sulfate sodium salt, ≥93%; Estriol, ≥97%; Estrone 3-sulfate sodium salt, contains ~35% Tris as stabilizer; β-Estradiol, ≥98%; α-Estradiol, powder, ≥98% (TLC); Estrone, ≥99%

UHPLC Analysis of Conjugated Estrogens on Titan™ C18

The Titan C18 column provided efficient and rapid resolution of thirteen related estrogenic compounds. Ultra Ultra high purity solvents provided robust operation.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service