T1694
(E)-4-Amino-2-butenoic acid
Synonym(s):
trans-4-Aminocrotonic acid, TACA
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About This Item
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form
powder
color
white
solubility
H2O: 10 mg/mL, clear
SMILES string
NC\C=C\C(O)=O
InChI
1S/C4H7NO2/c5-3-1-2-4(6)7/h1-2H,3,5H2,(H,6,7)/b2-1+
InChI key
FMKJUUQOYOHLTF-OWOJBTEDSA-N
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Pharmacological reports : PR, 57(1), 121-123 (2005-04-26)
In the present study, we evaluated TACA (a potent agonist of GABA(A) and GABA(C) receptors) in the electroconvulsive threshold test in mice. Surprisingly, TACA (at 15 and 25 mg/kg) significantly decreased the threshold. The highest ineffective dose of TACA was
Trends in pharmacological sciences, 22(3), 121-132 (2001-03-10)
In less than a decade our knowledge of the GABA(C) receptor, a new type of Cl(-)-permeable ionotropic GABA receptor, has greatly increased based on studies of both native and recombinant receptors. Careful comparison of properties of native and recombinant receptors
American journal of physiology. Renal physiology, 308(9), F1020-F1025 (2015-01-23)
Adenosine plays an important role in regulation of renal microcirculation. All receptors of adenosine, A1, A2A, A2B, and A3, have been found in the kidney. However, little is known about the location and function of the A3 receptor in the
Nature communications, 4, 1702-1702 (2013-04-18)
Achieving significant adhesion to soft tissues while minimizing tissue damage poses a considerable clinical challenge. Chemical-based adhesives require tissue-specific reactive chemistry, typically inducing a significant inflammatory response. Staples are fraught with limitations including high-localized tissue stress and increased risk of
PLoS genetics, 8(7), e1002702-e1002702 (2012-07-26)
RNA interference (RNAi)-related pathways affect gene activity by sequence-specific recruitment of Ago proteins to mRNA target molecules. The sequence specificity of this process stems from small RNA (sRNA) co-factors bound by the Ago protein. Stability of sRNA molecules in some
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